DegronMD - P54296(MYOM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A508T	TCGA-69-8255	LUAD	TCGA	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.A508T	DO25360	LUAD	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.A508T	SIDM02059	Colorectal Carcinoma	GDSC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.A508T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.A508T	ACH-001669	Leukemia	CCLE	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.A508T	ACH-002238	Leukemia	CCLE	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.A508T	GR-ST	haematopoietic and lymphoid tissue	COSMIC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.A488T	TCGA-95-A4VN	LUAD	TCGA	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.A488T	DO51199	LUAD	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.A488S	TCGA-AX-A06F	UCEC	TCGA	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.A488S	TCGA-DD-AAC8	LIHC	TCGA	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.A488S	DO52193	LIHC	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.A488S	DO41752	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.E496D	TCGA-AX-A2HC	UCEC	TCGA	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.E496D	DO41572	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.A488V	TCGA-B5-A3FA	UCEC	TCGA	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.A488V	DO52402	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.0833
p.V489A	TCGA-D1-A103	UCEC	TCGA	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1111
p.V489A	DO42312	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1111
p.Q501E	TCGA-HF-7131	STAD	TCGA	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.5633
p.Q501E	DO222730	ESCA	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.5633
p.Q501E	DO38208	STAD	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.5633
p.A498G	DO230319	COCA	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.6429
p.S506N	DO222798	COCA	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2222
p.T495I	DO20755	KIRP	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2778
p.C491R	DO229289	LMS	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1667
p.I489S	DO52647	MALY	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1111
p.D503N	DO218904	SKCA	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.E496G	DO229229	THCA	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.3056
p.E499D	DO41572	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.6758
p.R504Q	DO41572	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2778
p.R504Q	BPH-1	prostate	COSMIC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2778
p.S506I	DO42793	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2222
p.M502I	DO42673	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.7618

Kaplan plot for MYOM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYOM2

UniProt ID: P54296

Entrez ID: 9172

Protein name: Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYOM2 in