DegronMD

Uniprot ID: P54296

Source protein: Myomesin-2

Source gene: MYOM2

Class: LIG_APCC_ABBA_1

Location: 497:502

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5258

ASA_SCORE: 53.65

COIL: 0.2958

CONS_SCORE: 0.3874

DSS_SCORE: 0.4375

HELIX: 0.1447

FCONS_SCORE: 0.9206

RIG_SCORE: 0.8233

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A508T	TCGA-69-8255	LUAD	TCGA	IAIYQD	LIG_APCC_ABBA_1	0.1667
p.A508T	DO25360	LUAD	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.1667
p.A508T	SIDM02059	Colorectal Carcinoma	GDSC	IAIYQD	LIG_APCC_ABBA_1	0.1667
p.A508T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	IAIYQD	LIG_APCC_ABBA_1	0.1667
p.A508T	ACH-001669	Leukemia	CCLE	IAIYQD	LIG_APCC_ABBA_1	0.1667
p.A508T	ACH-002238	Leukemia	CCLE	IAIYQD	LIG_APCC_ABBA_1	0.1667
p.A508T	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	IAIYQD	LIG_APCC_ABBA_1	0.1667
p.A488T	TCGA-95-A4VN	LUAD	TCGA	IAIYQD	LIG_APCC_ABBA_1	0.0833
p.A488T	DO51199	LUAD	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.0833
p.A488S	TCGA-AX-A06F	UCEC	TCGA	IAIYQD	LIG_APCC_ABBA_1	0.0833
p.A488S	TCGA-DD-AAC8	LIHC	TCGA	IAIYQD	LIG_APCC_ABBA_1	0.0833
p.A488S	DO52193	LIHC	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.0833
p.A488S	DO41752	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.0833
p.E496D	TCGA-AX-A2HC	UCEC	TCGA	IAIYQD	LIG_APCC_ABBA_1	0.3056
p.E496D	DO41572	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.3056
p.A488V	TCGA-B5-A3FA	UCEC	TCGA	IAIYQD	LIG_APCC_ABBA_1	0.0833
p.A488V	DO52402	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.0833
p.V489A	TCGA-D1-A103	UCEC	TCGA	IAIYQD	LIG_APCC_ABBA_1	0.1111
p.V489A	DO42312	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.1111
p.Q501E	TCGA-HF-7131	STAD	TCGA	IAIYQD	LIG_APCC_ABBA_1	0.5633
p.Q501E	DO222730	ESCA	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.5633
p.Q501E	DO38208	STAD	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.5633
p.A498G	DO230319	COCA	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.6429
p.S506N	DO222798	COCA	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.2222
p.T495I	DO20755	KIRP	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.2778
p.C491R	DO229289	LMS	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.1667
p.I489S	DO52647	MALY	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.1111
p.D503N	DO218904	SKCA	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.3056
p.E496G	DO229229	THCA	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.3056
p.E499D	DO41572	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.6758
p.R504Q	DO41572	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.2778
p.R504Q	BPH-1	prostate	COSMIC	IAIYQD	LIG_APCC_ABBA_1	0.2778
p.S506I	DO42793	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.2222
p.M502I	DO42673	UCEC	ICGC	IAIYQD	LIG_APCC_ABBA_1	0.7618

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAIYQD

Degron related mutations and impact score

Drug responses associated with MYOM2 mutations

All proteins holding degron of IAIYQD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54296	Myomesin-2	LIG_APCC_ABBA_1	497:502	IAIYQD	APC,CDC20,FZR1	0.5258	More...