DegronMD - P54840(GYS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V690A	TCGA-06-5416	GBM	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.2222
p.V690A	DO10880	GBM	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.2222
p.G693V	TCGA-37-3792	LUSC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.3056
p.G693V	DO27192	LUSC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.3056
p.N703S	TCGA-52-7810	LUSC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.25
p.N703S	DO27381	LUSC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.25
p.H689N	TCGA-A5-A0G1	UCEC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.1944
p.H689N	DO42472	UCEC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.1944
p.K694N	TCGA-B5-A11N	UCEC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation altering degron motif	0.6918
p.K694N	DO41458	UCEC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation altering degron motif	0.6918
p.K702T	TCGA-B5-A1MX	UCEC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.2778
p.K702T	DO41999	UCEC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.2778
p.V690I	TCGA-EO-A22R	UCEC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.2222
p.V690I	DO42713	UCEC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.2222
p.P691T	TCGA-KQ-A41N	BLCA	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.25
p.P691T	DO223588	BLCA	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.25
p.P691R	DO1121	BRCA	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.25
p.L687P	SIDM01045	Endometrial Carcinoma	GDSC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.1389
p.L687P	ACH-000978	Endometrial/Uterine Cancer	CCLE	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.1389
p.L687P	EN	endometrium	COSMIC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	694:700	Mutation rewiring degron network	0.1389

Kaplan plot for GYS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GYS2

UniProt ID: P54840

Entrez ID: 2998

Protein name: Glycogen [starch] synthase, liver (EC 2.4.1.11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GYS2 in