DegronMD

Uniprot ID: P54840

Source protein: Glycogen [starch] synthase, liver

Source gene: GYS2

Class: LIG_APCC_ABBAyCdc20_2

Location: 694:700

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9825

ASA_SCORE: 111.7857

COIL: 0.9394

CONS_SCORE: 0.2461

DSS_SCORE: 0.7453

HELIX: 0.0426

FCONS_SCORE: 1.013

RIG_SCORE: 0.6456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V690A	TCGA-06-5416	GBM	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V690A	DO10880	GBM	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G693V	TCGA-37-3792	LUSC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G693V	DO27192	LUSC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.N703S	TCGA-52-7810	LUSC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.N703S	DO27381	LUSC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.H689N	TCGA-A5-A0G1	UCEC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.H689N	DO42472	UCEC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K694N	TCGA-B5-A11N	UCEC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K694N	DO41458	UCEC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K702T	TCGA-B5-A1MX	UCEC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K702T	DO41999	UCEC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V690I	TCGA-EO-A22R	UCEC	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V690I	DO42713	UCEC	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P691T	TCGA-KQ-A41N	BLCA	TCGA	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.P691T	DO223588	BLCA	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.P691R	DO1121	BRCA	ICGC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.L687P	SIDM01045	Endometrial Carcinoma	GDSC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.L687P	ACH-000978	Endometrial/Uterine Cancer	CCLE	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.L687P	EN	endometrium	COSMIC	KKKLHGE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54840	Glycogen [starch] synthase, liver	LIG_APCC_ABBAyCdc20_2	694:700	KKKLHGE	APC,CDC20,FZR1	0.9825	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons