DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KKKLHGE
Uniprot ID:
P54840
Source protein:
Glycogen [starch] synthase, liver
Source gene:
GYS2
Class:
LIG_APCC_ABBAyCdc20_2
Location:
694:700
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9825
ASA_SCORE:
111.7857
COIL:
0.9394
CONS_SCORE:
0.2461
DSS_SCORE:
0.7453
HELIX:
0.0426
FCONS_SCORE:
1.013
RIG_SCORE:
0.6456
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K694N
TCGA-B5-A11N
UCEC
TCGA
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.6918
p.K694N
DO41458
UCEC
ICGC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.6918
p.G693V
TCGA-37-3792
LUSC
TCGA
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.3056
p.G693V
DO27192
LUSC
ICGC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.3056
p.K702T
TCGA-B5-A1MX
UCEC
TCGA
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.2778
p.K702T
DO41999
UCEC
ICGC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.2778
p.N703S
TCGA-52-7810
LUSC
TCGA
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.25
p.N703S
DO27381
LUSC
ICGC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.25
p.P691T
TCGA-KQ-A41N
BLCA
TCGA
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.25
p.P691T
DO223588
BLCA
ICGC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.25
p.P691R
DO1121
BRCA
ICGC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.25
p.V690A
TCGA-06-5416
GBM
TCGA
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.2222
p.V690A
DO10880
GBM
ICGC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.2222
p.V690I
TCGA-EO-A22R
UCEC
TCGA
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.2222
p.V690I
DO42713
UCEC
ICGC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.2222
p.H689N
TCGA-A5-A0G1
UCEC
TCGA
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.1944
p.H689N
DO42472
UCEC
ICGC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.1944
p.L687P
SIDM01045
Endometrial Carcinoma
GDSC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.1389
p.L687P
ACH-000978
Endometrial/Uterine Cancer
CCLE
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.1389
p.L687P
EN
endometrium
COSMIC
KKKLHGE
LIG_APCC_ABBAyCdc20_2
0.1389
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Drug responses associated with GYS2 mutations
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Mutation (In Degron?)
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All proteins holding degron of KKKLHGE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P54840
Glycogen [starch] synthase, liver
LIG_APCC_ABBAyCdc20_2
694:700
KKKLHGE
APC,CDC20,FZR1
0.9825
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