SLC12A2
UniProt ID: P55011
Entrez ID: 6558
Protein name: Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:32294086). Plays a vital role in the regulation of ionic balance and cell volume. {ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0...
FUNCTION: Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:32294086). Plays a vital role in the regulation of ionic balance and cell volume. {ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:7629105}.
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GO - Biological processes (BP):
aging [GO:0007568]; ammonium transmembrane transport [GO:0072488]; cellular chloride ion homeostasis [GO:0030644]; cellular potassium ion homeostasis [GO:0030007]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; cellular sodium ion homeostasis [GO:000688...
aging [GO:0007568]; ammonium transmembrane transport [GO:0072488]; cellular chloride ion homeostasis [GO:0030644]; cellular potassium ion homeostasis [GO:0030007]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; cellular sodium ion homeostasis [GO:0006883]; cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hyperosmotic response [GO:0006972]; inorganic anion import across plasma membrane [GO:0098658]; inorganic cation import across plasma membrane [GO:0098659]; ion transport [GO:0006811]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of vascular wound healing [GO:0061044]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of cell volume [GO:0045795]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of spontaneous synaptic transmission [GO:0150003]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; T cell chemotaxis [GO:0010818]; transepithelial ammonium transport [GO:0070634]; transepithelial chloride transport [GO:0030321]; transport across blood-brain barrier [GO:0150104]
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GO - Molecular function (MF):
ammonium transmembrane transporter activity [GO:0008519]; cation:chloride symporter activity [GO:0015377]; chaperone binding [GO:0051087]; Hsp90 protein binding [GO:0051879]; metal ion transmembrane transporter activity [GO:0046873]; potassium:chloride symporter activity [GO:0015379]; potassium ion ...
ammonium transmembrane transporter activity [GO:0008519]; cation:chloride symporter activity [GO:0015377]; chaperone binding [GO:0051087]; Hsp90 protein binding [GO:0051879]; metal ion transmembrane transporter activity [GO:0046873]; potassium:chloride symporter activity [GO:0015379]; potassium ion transmembrane transporter activity [GO:0015079]; protein kinase binding [GO:0019901]; sodium:potassium:chloride symporter activity [GO:0008511]
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GO - Cellular component (CC):
apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell body membrane [GO:0044298]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cell projection membrane [GO:0031253]; cytoplasmic vesicle membrane [...
apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell body membrane [GO:0044298]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cell projection membrane [GO:0031253]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; integral component of plasma membrane [GO:0005887]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]
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SLC12A2
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Kaplan plot for SLC12A2 in
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*NOTE: the Kaplan plots were collected from OncoLnc