DegronMD

Uniprot ID: P55011

Source protein: Solute carrier family 12 member 2

Source gene: SLC12A2

Class: DEG_APCC_DBOX_1

Location: 239:247

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9982

ASA_SCORE: 65.0667

COIL: 0.4601

CONS_SCORE: 0.3706

DSS_SCORE: 0.4764

HELIX: 0.5177

FCONS_SCORE: 1.2684

RIG_SCORE: 0.7272

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D257Y	DO229018	LICA	ICGC	LRPSLAELH	DEG_APCC_DBOX_1	0.0556
p.D248E	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	LRPSLAELH	DEG_APCC_DBOX_1	0.3056
p.D248E	COR-L105	lung	COSMIC	LRPSLAELH	DEG_APCC_DBOX_1	0.3056
p.D257G	SIDM01622	Breast Carcinoma	GDSC	LRPSLAELH	DEG_APCC_DBOX_1	0.0556
p.D257G	ACH-000721	Breast Cancer	CCLE	LRPSLAELH	DEG_APCC_DBOX_1	0.0556
p.L243P	ACH-000564	Myeloma	CCLE	LRPSLAELH	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55011	Solute carrier family 12 member 2	DEG_APCC_DBOX_1	239:247	LRPSLAELH	APC,CDC20,FZR1	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons