DegronMD - P55036(PSMD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E283K	TCGA-25-1323	OV	TCGA	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.E283K	DO29810	OV	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.R272C	TCGA-A5-A0G2	UCEC	TCGA	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8301
p.R272C	DO41235	UCEC	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8301
p.E283Q	TCGA-DK-A1AF	BLCA	TCGA	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.E283Q	DO633	BLCA	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.Q268E	DO225390	BRCA	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.25
p.Q267H	DO229019	LICA	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.Q267H	DO46873	RECA	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.Q270L	SIDM01117	Small Cell Lung Carcinoma	GDSC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.3056
p.Q270L	NCI-H748	lung	COSMIC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.3056
p.T264A	ACH-002069	Bone Cancer	CCLE	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.1389
p.R272H	ACH-002089	Lung Cancer	CCLE	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8244
p.R272H	201T	lung	COSMIC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8244
p.Q267L	ACH-002176	Lung Cancer	CCLE	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.Q267L	NCI-H748	lung	COSMIC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.R275H	201T	lung	COSMIC	GRTGLPDLS	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8244

Kaplan plot for PSMD4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSMD4

UniProt ID: P55036

Entrez ID: 5710

Protein name: 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSMD4 in