DegronMD

Uniprot ID: P55036

Source protein: 26S proteasome non-ATPase regulatory subunit 4

Source gene: PSMD4

Class: DEG_APCC_DBOX_1

Location: 271:279

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9764

ASA_SCORE: 77.2444

COIL: 0.7977

CONS_SCORE: 0.2684

DSS_SCORE: 0.5641

HELIX: 0.1673

FCONS_SCORE: 0.7094

RIG_SCORE: 0.7067

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E283K	TCGA-25-1323	OV	TCGA	GRTGLPDLS	DEG_APCC_DBOX_1	0.2222
p.E283K	DO29810	OV	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	0.2222
p.R272C	TCGA-A5-A0G2	UCEC	TCGA	GRTGLPDLS	DEG_APCC_DBOX_1	0.8301
p.R272C	DO41235	UCEC	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	0.8301
p.E283Q	TCGA-DK-A1AF	BLCA	TCGA	GRTGLPDLS	DEG_APCC_DBOX_1	0.2222
p.E283Q	DO633	BLCA	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	0.2222
p.Q268E	DO225390	BRCA	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	0.25
p.Q267H	DO229019	LICA	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	0.2222
p.Q267H	DO46873	RECA	ICGC	GRTGLPDLS	DEG_APCC_DBOX_1	0.2222
p.Q270L	SIDM01117	Small Cell Lung Carcinoma	GDSC	GRTGLPDLS	DEG_APCC_DBOX_1	0.3056
p.Q270L	NCI-H748	lung	COSMIC	GRTGLPDLS	DEG_APCC_DBOX_1	0.3056
p.T264A	ACH-002069	Bone Cancer	CCLE	GRTGLPDLS	DEG_APCC_DBOX_1	0.1389
p.R272H	ACH-002089	Lung Cancer	CCLE	GRTGLPDLS	DEG_APCC_DBOX_1	0.8244
p.R272H	201T	lung	COSMIC	GRTGLPDLS	DEG_APCC_DBOX_1	0.8244
p.Q267L	ACH-002176	Lung Cancer	CCLE	GRTGLPDLS	DEG_APCC_DBOX_1	0.2222
p.Q267L	NCI-H748	lung	COSMIC	GRTGLPDLS	DEG_APCC_DBOX_1	0.2222
p.R275H	201T	lung	COSMIC	GRTGLPDLS	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55036	26S proteasome non-ATPase regulatory subunit 4	DEG_APCC_DBOX_1	271:279	GRTGLPDLS	APC,CDC20,FZR1	0.9764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons