DegronMD - P55107(GDF10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V114M	TCGA-A5-A2K3	UCEC	TCGA	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2222
p.V114M	DO229489	LAML	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2222
p.V114M	DO43899	UCEC	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2222
p.R100C	TCGA-B5-A3FA	UCEC	TCGA	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.R100C	DO52402	UCEC	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.R103S	TCGA-FI-A2F4	UCEC	TCGA	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.7427
p.R103S	DO43434	UCEC	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.7427
p.G96V	DO233770	GACA	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1667
p.G96S	DO50970	LICA	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1667
p.P93L	DO229245	THCA	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.R100H	SIDM01307	Colorectal Carcinoma	GDSC	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.S101N	SIDM00301	Pancreatic Carcinoma	GDSC	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.S101N	ACH-000265	Pancreatic Cancer	CCLE	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.A113V	SIDM00528	Breast Carcinoma	GDSC	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.25
p.A113V	ACH-000934	Breast Cancer	CCLE	FRARLEVVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.25

Kaplan plot for GDF10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GDF10

UniProt ID: P55107

Entrez ID: 2662

Protein name: Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GDF10 in