DegronMD

Uniprot ID: P55107

Source protein: Growth/differentiation factor 10

Source gene: GDF10

Class: DEG_APCC_DBOX_1

Location: 102:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6203

ASA_SCORE: 76.5222

COIL: 0.3642

CONS_SCORE: 0.4863

DSS_SCORE: 0.1657

HELIX: 0.0353

FCONS_SCORE: 0.7979

RIG_SCORE: 0.8762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V114M	TCGA-A5-A2K3	UCEC	TCGA	FRARLEVVD	DEG_APCC_DBOX_1	0.2222
p.V114M	DO229489	LAML	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	0.2222
p.V114M	DO43899	UCEC	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	0.2222
p.R100C	TCGA-B5-A3FA	UCEC	TCGA	FRARLEVVD	DEG_APCC_DBOX_1	0.2778
p.R100C	DO52402	UCEC	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	0.2778
p.R103S	TCGA-FI-A2F4	UCEC	TCGA	FRARLEVVD	DEG_APCC_DBOX_1	0.7427
p.R103S	DO43434	UCEC	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	0.7427
p.G96V	DO233770	GACA	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	0.1667
p.G96S	DO50970	LICA	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	0.1667
p.P93L	DO229245	THCA	ICGC	FRARLEVVD	DEG_APCC_DBOX_1	0.0833
p.R100H	SIDM01307	Colorectal Carcinoma	GDSC	FRARLEVVD	DEG_APCC_DBOX_1	0.2778
p.S101N	SIDM00301	Pancreatic Carcinoma	GDSC	FRARLEVVD	DEG_APCC_DBOX_1	0.3056
p.S101N	ACH-000265	Pancreatic Cancer	CCLE	FRARLEVVD	DEG_APCC_DBOX_1	0.3056
p.A113V	SIDM00528	Breast Carcinoma	GDSC	FRARLEVVD	DEG_APCC_DBOX_1	0.25
p.A113V	ACH-000934	Breast Cancer	CCLE	FRARLEVVD	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55107	Growth/differentiation factor 10	DEG_APCC_DBOX_1	102:110	FRARLEVVD	APC,CDC20,FZR1	0.6203	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons