DegronMD - P55157(MTTP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q872L	TCGA-23-1117	OV	TCGA	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation altering degron motif	0.6654
p.Q872L	DO30830	OV	ICGC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation altering degron motif	0.6654
p.E873D	TCGA-AA-3977	COAD	TCGA	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation altering degron motif	0.5647
p.E873D	DO8730	COAD	ICGC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation altering degron motif	0.5647
p.E873D	DO222762	COCA	ICGC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation altering degron motif	0.5647
p.E873D	HCC2998	large intestine	COSMIC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation altering degron motif	0.5647
p.N874K	TCGA-AA-A02K	COAD	TCGA	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation rewiring degron network	0.3056
p.N874K	DO9812	COAD	ICGC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation rewiring degron network	0.3056
p.E867K	TCGA-B6-A0WZ	BRCA	TCGA	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation rewiring degron network	0.3056
p.E867K	DO1972	BRCA	ICGC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation rewiring degron network	0.3056
p.V862I	TCGA-HU-A4G9	STAD	TCGA	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation rewiring degron network	0.1667
p.V862I	DO46794	PRAD	ICGC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation rewiring degron network	0.1667
p.V862I	DO47789	STAD	ICGC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation rewiring degron network	0.1667
p.V862I	LNCaP-Clone-FGC	prostate	COSMIC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation rewiring degron network	0.1667
p.L870F	CW-2	large intestine	COSMIC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation altering degron motif	0.6981
p.C878Y	RKO	large intestine	COSMIC	FPLHQE	LIG_APCC_ABBA_1	868:873	Mutation rewiring degron network	0.1944

Kaplan plot for MTTP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTTP

UniProt ID: P55157

Entrez ID: 4547

Protein name: Microsomal triglyceride transfer protein large subunit

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTTP in