DegronMD

Uniprot ID: P55157

Source protein: Microsomal triglyceride transfer protein large subunit

Source gene: MTTP

Class: LIG_APCC_ABBA_1

Location: 868:873

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6082

ASA_SCORE: 76.4

COIL: 0.4358

CONS_SCORE: 0.6081

DSS_SCORE: 0.2055

HELIX: 0.3457

FCONS_SCORE: 1.2357

RIG_SCORE: 0.7847

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q872L	TCGA-23-1117	OV	TCGA	FPLHQE	LIG_APCC_ABBA_1	0.6654
p.Q872L	DO30830	OV	ICGC	FPLHQE	LIG_APCC_ABBA_1	0.6654
p.E873D	TCGA-AA-3977	COAD	TCGA	FPLHQE	LIG_APCC_ABBA_1	0.5647
p.E873D	DO8730	COAD	ICGC	FPLHQE	LIG_APCC_ABBA_1	0.5647
p.E873D	DO222762	COCA	ICGC	FPLHQE	LIG_APCC_ABBA_1	0.5647
p.E873D	HCC2998	large_intestine	COSMIC	FPLHQE	LIG_APCC_ABBA_1	0.5647
p.N874K	TCGA-AA-A02K	COAD	TCGA	FPLHQE	LIG_APCC_ABBA_1	0.3056
p.N874K	DO9812	COAD	ICGC	FPLHQE	LIG_APCC_ABBA_1	0.3056
p.E867K	TCGA-B6-A0WZ	BRCA	TCGA	FPLHQE	LIG_APCC_ABBA_1	0.3056
p.E867K	DO1972	BRCA	ICGC	FPLHQE	LIG_APCC_ABBA_1	0.3056
p.V862I	TCGA-HU-A4G9	STAD	TCGA	FPLHQE	LIG_APCC_ABBA_1	0.1667
p.V862I	DO46794	PRAD	ICGC	FPLHQE	LIG_APCC_ABBA_1	0.1667
p.V862I	DO47789	STAD	ICGC	FPLHQE	LIG_APCC_ABBA_1	0.1667
p.V862I	LNCaP-Clone-FGC	prostate	COSMIC	FPLHQE	LIG_APCC_ABBA_1	0.1667
p.L870F	CW-2	large_intestine	COSMIC	FPLHQE	LIG_APCC_ABBA_1	0.6981
p.C878Y	RKO	large_intestine	COSMIC	FPLHQE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55157	Microsomal triglyceride transfer protein large subunit	LIG_APCC_ABBA_1	868:873	FPLHQE	APC,CDC20,FZR1	0.6082	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons