DegronMD - P55210(CASP7)

CASP7

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q33K	TCGA-AP-A0LM	UCEC	TCGA	DRSSFVPSL	DEG_COP1_1	27:35	Mutation altering degron motif	0.6944
p.Q33K	DO43306	UCEC	ICGC	DRSSFVPSL	DEG_COP1_1	27:35	Mutation altering degron motif	0.6944
p.T18A	TCGA-B5-A11E	UCEC	TCGA	DRSSFVPSL	DEG_COP1_1	27:35	Mutation rewiring degron network	0.0833
p.T18A	DO41644	UCEC	ICGC	DRSSFVPSL	DEG_COP1_1	27:35	Mutation rewiring degron network	0.0833
p.D36N	TCGA-B6-A0WZ	BRCA	TCGA	DRSSFVPSL	DEG_COP1_1	27:35	Mutation rewiring degron network	0.3056
p.D36N	DO1972	BRCA	ICGC	DRSSFVPSL	DEG_COP1_1	27:35	Mutation rewiring degron network	0.3056
p.D37E	DO230990	LUSC	ICGC	DRSSFVPSL	DEG_COP1_1	27:35	Mutation blocking phosphorylation signal	0.7222
p.S34Y	ACH-001655	Endometrial/Uterine Cancer	CCLE	DRSSFVPSL	DEG_COP1_1	27:35	Mutation altering degron motif	0.8231
p.S34Y	SKN	soft tissue	COSMIC	DRSSFVPSL	DEG_COP1_1	27:35	Mutation altering degron motif	0.8231
p.A28V	NCI-H630	large intestine	COSMIC	DRSSFVPSL	DEG_COP1_1	27:35	Mutation altering degron motif	0.6936
p.R28W	KYSE-450	oesophagus	COSMIC	DRSSFVPSL	DEG_COP1_1	27:35	Mutation altering degron motif	0.7523

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*NOTE: the Kaplan plots were collected from OncoLnc