DegronMD

Uniprot ID: P55210

Source protein: Caspase-7

Source gene: CASP7

Class: DEG_COP1_1

Location: 27:35

E3 ligase: COP1

DEGRON score: 0.9123

ASA_SCORE: 84.7111

COIL: 0.7886

CONS_SCORE: 0.2657

DSS_SCORE: 0.5076

HELIX: 0.1731

FCONS_SCORE: 0.8796

RIG_SCORE: 0.7085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q33K	TCGA-AP-A0LM	UCEC	TCGA	DRSSFVPSL	DEG_COP1_1	0.6944
p.Q33K	DO43306	UCEC	ICGC	DRSSFVPSL	DEG_COP1_1	0.6944
p.T18A	TCGA-B5-A11E	UCEC	TCGA	DRSSFVPSL	DEG_COP1_1	0.0833
p.T18A	DO41644	UCEC	ICGC	DRSSFVPSL	DEG_COP1_1	0.0833
p.D36N	TCGA-B6-A0WZ	BRCA	TCGA	DRSSFVPSL	DEG_COP1_1	0.3056
p.D36N	DO1972	BRCA	ICGC	DRSSFVPSL	DEG_COP1_1	0.3056
p.D37E	DO230990	LUSC	ICGC	DRSSFVPSL	DEG_COP1_1	0.7222
p.S34Y	ACH-001655	Endometrial/Uterine Cancer	CCLE	DRSSFVPSL	DEG_COP1_1	0.8231
p.S34Y	SKN	soft_tissue	COSMIC	DRSSFVPSL	DEG_COP1_1	0.8231
p.A28V	NCI-H630	large_intestine	COSMIC	DRSSFVPSL	DEG_COP1_1	0.6936
p.R28W	KYSE-450	oesophagus	COSMIC	DRSSFVPSL	DEG_COP1_1	0.7523

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55210	Caspase-7	DEG_COP1_1	27:35	DRSSFVPSL	COP1	0.9123	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons