DegronMD - P55285(CDH6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S172F	TCGA-23-2078	OV	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.3056
p.S172F	DO31829	OV	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.3056
p.M171I	TCGA-55-A490	LUAD	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6507
p.M171I	DO24596	LUAD	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6507
p.K161E	TCGA-69-7979	LUAD	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.3056
p.K161E	DO23874	LUAD	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.3056
p.F177C	TCGA-AA-3977	COAD	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1667
p.F177C	DO8730	COAD	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1667
p.P169L	TCGA-AC-A5EH	BRCA	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.7582
p.P169L	DO223931	BRCA	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.7582
p.P169T	TCGA-AP-A1DK	UCEC	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.7031
p.P169T	DO42033	UCEC	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.7031
p.N155D	TCGA-CM-6171	COAD	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1389
p.N155D	DO8151	COAD	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1389
p.E170Q	TCGA-D1-A3DH	UCEC	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6744
p.E170Q	DO43482	UCEC	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6744
p.T176A	TCGA-D3-A8GD	SKCM	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1944
p.T176A	DO50282	SKCM	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1944
p.T160A	TCGA-E6-A1LX	UCEC	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2778
p.T160A	DO41020	UCEC	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2778
p.V163D	TCGA-ER-A19F	SKCM	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6674
p.V163D	DO37679	SKCM	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6674
p.D154N	TCGA-FS-A4F5	SKCM	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1111
p.D154N	DO37881	SKCM	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1111
p.D173N	TCGA-T3-A92M	HNSC	TCGA	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2778
p.D173N	DO223269	HNSC	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2778
p.D173N	DO230946	LUSC	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2778
p.D173N	DO224605	LUSC	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2778
p.G175S	DO227984	COCA	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175S	SIDM00553	Acute Myeloid Leukemia	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175S	SIDM01164	Glioma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175S	KY821	haematopoietic and lymphoid tissue	COSMIC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175S	SW1783	central nervous system	COSMIC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.V178F	DO229028	LICA	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1389
p.G175V	DO229032	LICA	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.V163A	DO229459	SKCA	ICGC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.5825
p.G175D	SIDM00608	Plasma Cell Myeloma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	SIDM00281	Other Solid Cancers	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	SIDM00465	Ovarian Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	SIDM00568	Gastric Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	SIDM00242	Osteosarcoma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	SIDM00616	Hepatocellular Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	SIDM00603	Head and Neck Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	SIDM01776	Plasma Cell Myeloma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	SIDM01433	Kidney Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	SIDM01588	Endometrial Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.G175D	SIDM01443	Gastric Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.2222
p.N168D	HCT-15	large intestine	COSMIC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.6932
p.S157L	HCT-15	large intestine	COSMIC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.1944
p.V180L	A498	kidney	COSMIC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation rewiring degron network	0.0833
p.E162D	Daudi	haematopoietic and lymphoid tissue	COSMIC	EVYTATVPEM	DEG_COP1_1	162:171	Mutation altering degron motif	0.5647

Kaplan plot for CDH6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH6

UniProt ID: P55285

Entrez ID: 1004

Protein name: Cadherin-6 (Kidney cadherin) (K-cadherin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH6 in