DegronMD

Uniprot ID: P55285

Source protein: Cadherin-6

Source gene: CDH6

Class: DEG_COP1_1

Location: 162:171

E3 ligase: COP1

DEGRON score: 0.6262

ASA_SCORE: 51.48

COIL: 0.3199

CONS_SCORE: 0.7432

DSS_SCORE: 0.2876

HELIX: 0.0121

FCONS_SCORE: 0.9233

RIG_SCORE: 0.8401

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S172F	TCGA-23-2078	OV	TCGA	EVYTATVPEM	DEG_COP1_1	0.3056
p.S172F	DO31829	OV	ICGC	EVYTATVPEM	DEG_COP1_1	0.3056
p.M171I	TCGA-55-A490	LUAD	TCGA	EVYTATVPEM	DEG_COP1_1	0.6507
p.M171I	DO24596	LUAD	ICGC	EVYTATVPEM	DEG_COP1_1	0.6507
p.K161E	TCGA-69-7979	LUAD	TCGA	EVYTATVPEM	DEG_COP1_1	0.3056
p.K161E	DO23874	LUAD	ICGC	EVYTATVPEM	DEG_COP1_1	0.3056
p.F177C	TCGA-AA-3977	COAD	TCGA	EVYTATVPEM	DEG_COP1_1	0.1667
p.F177C	DO8730	COAD	ICGC	EVYTATVPEM	DEG_COP1_1	0.1667
p.P169L	TCGA-AC-A5EH	BRCA	TCGA	EVYTATVPEM	DEG_COP1_1	0.7582
p.P169L	DO223931	BRCA	ICGC	EVYTATVPEM	DEG_COP1_1	0.7582
p.P169T	TCGA-AP-A1DK	UCEC	TCGA	EVYTATVPEM	DEG_COP1_1	0.7031
p.P169T	DO42033	UCEC	ICGC	EVYTATVPEM	DEG_COP1_1	0.7031
p.N155D	TCGA-CM-6171	COAD	TCGA	EVYTATVPEM	DEG_COP1_1	0.1389
p.N155D	DO8151	COAD	ICGC	EVYTATVPEM	DEG_COP1_1	0.1389
p.E170Q	TCGA-D1-A3DH	UCEC	TCGA	EVYTATVPEM	DEG_COP1_1	0.6744
p.E170Q	DO43482	UCEC	ICGC	EVYTATVPEM	DEG_COP1_1	0.6744
p.T176A	TCGA-D3-A8GD	SKCM	TCGA	EVYTATVPEM	DEG_COP1_1	0.1944
p.T176A	DO50282	SKCM	ICGC	EVYTATVPEM	DEG_COP1_1	0.1944
p.T160A	TCGA-E6-A1LX	UCEC	TCGA	EVYTATVPEM	DEG_COP1_1	0.2778
p.T160A	DO41020	UCEC	ICGC	EVYTATVPEM	DEG_COP1_1	0.2778
p.V163D	TCGA-ER-A19F	SKCM	TCGA	EVYTATVPEM	DEG_COP1_1	0.6674
p.V163D	DO37679	SKCM	ICGC	EVYTATVPEM	DEG_COP1_1	0.6674
p.D154N	TCGA-FS-A4F5	SKCM	TCGA	EVYTATVPEM	DEG_COP1_1	0.1111
p.D154N	DO37881	SKCM	ICGC	EVYTATVPEM	DEG_COP1_1	0.1111
p.D173N	TCGA-T3-A92M	HNSC	TCGA	EVYTATVPEM	DEG_COP1_1	0.2778
p.D173N	DO223269	HNSC	ICGC	EVYTATVPEM	DEG_COP1_1	0.2778
p.D173N	DO230946	LUSC	ICGC	EVYTATVPEM	DEG_COP1_1	0.2778
p.D173N	DO224605	LUSC	ICGC	EVYTATVPEM	DEG_COP1_1	0.2778
p.G175S	DO227984	COCA	ICGC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175S	SIDM00553	Acute Myeloid Leukemia	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175S	SIDM01164	Glioma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175S	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175S	SW1783	central_nervous_system	COSMIC	EVYTATVPEM	DEG_COP1_1	0.2222
p.V178F	DO229028	LICA	ICGC	EVYTATVPEM	DEG_COP1_1	0.1389
p.G175V	DO229032	LICA	ICGC	EVYTATVPEM	DEG_COP1_1	0.2222
p.V163A	DO229459	SKCA	ICGC	EVYTATVPEM	DEG_COP1_1	0.5825
p.G175D	SIDM00608	Plasma Cell Myeloma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175D	SIDM00281	Other Solid Cancers	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175D	SIDM00465	Ovarian Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175D	SIDM00568	Gastric Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175D	SIDM00242	Osteosarcoma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175D	SIDM00616	Hepatocellular Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175D	SIDM00603	Head and Neck Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175D	SIDM01776	Plasma Cell Myeloma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175D	SIDM01433	Kidney Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175D	SIDM01588	Endometrial Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.G175D	SIDM01443	Gastric Carcinoma	GDSC	EVYTATVPEM	DEG_COP1_1	0.2222
p.N168D	HCT-15	large_intestine	COSMIC	EVYTATVPEM	DEG_COP1_1	0.6932
p.S157L	HCT-15	large_intestine	COSMIC	EVYTATVPEM	DEG_COP1_1	0.1944
p.V180L	A498	kidney	COSMIC	EVYTATVPEM	DEG_COP1_1	0.0833
p.E162D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	EVYTATVPEM	DEG_COP1_1	0.5647

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EVYTATVPEM

Degron related mutations and impact score

Drug responses associated with CDH6 mutations

All proteins holding degron of EVYTATVPEM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55285	Cadherin-6	DEG_COP1_1	162:171	EVYTATVPEM	COP1	0.6262	More...