DegronMD - P55286(CDH8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L704F	TCGA-32-4213	GBM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2222
p.L704F	DO11483	GBM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2222
p.D699Y	TCGA-46-3769	LUSC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.0833
p.D699Y	DO26590	LUSC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.0833
p.M707I	TCGA-55-7994	LUAD	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.3056
p.M707I	DO45311	LUAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.3056
p.R709W	TCGA-95-A4VK	LUAD	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.8634
p.D720H	TCGA-98-8021	LUSC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2222
p.D720H	DO27468	LUSC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2222
p.V715F	TCGA-A5-A0G2	UCEC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.7068
p.V715F	DO41235	UCEC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.7068
p.D699A	TCGA-A5-A0G2	UCEC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.0833
p.D699A	DO41235	UCEC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.0833
p.G718C	TCGA-BF-A1Q0	SKCM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2778
p.G718C	DO47374	SKCM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2778
p.F724C	TCGA-BR-8384	STAD	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1111
p.F724C	DO47749	STAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1111
p.K698N	TCGA-BR-8677	STAD	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation substituting flanking lysine	0.1667
p.K698N	DO47759	STAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation substituting flanking lysine	0.1667
p.P716S	TCGA-D3-A1QA	SKCM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.5641
p.P716S	DO222880	MELA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.5641
p.P716S	DO47469	SKCM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.5641
p.D699N	TCGA-D3-A3MV	SKCM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.0833
p.D699N	DO222557	MELA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.0833
p.D699N	DO37727	SKCM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.0833
p.D722N	TCGA-D3-A5GO	SKCM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1667
p.D722N	DO47419	SKCM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1667
p.K698R	TCGA-DD-AACC	LIHC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation substituting flanking lysine	0.1667
p.K698R	DO52198	LIHC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation substituting flanking lysine	0.1667
p.P714S	TCGA-EB-A41A	SKCM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.5641
p.P714S	DO37429	SKCM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.5641
p.R709M	TCGA-EO-A22R	UCEC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.8632
p.R709M	DO42713	UCEC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.8632
p.Q705P	TCGA-G4-6317	COAD	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.25
p.Q705P	DO10100	COAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.25
p.Q703R	DO228483	BRCA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1944
p.Q703R	DO234285	ESAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1944
p.Q703R	DO229346	LAML	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1944
p.G699D	DO230343	COCA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.0833
p.G699D	DO11854	GBM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.0833
p.L724P	DO234152	ESAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1111
p.K712T	DO234442	ESAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.7306
p.K698T	DO233137	GACA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation substituting flanking lysine	0.1667
p.P708T	DO229045	LICA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.5919
p.P708T	DO230999	LUSC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.5919
p.P708T	DO224551	LUSC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.5919
p.P710S	DO50970	LICA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.6752
p.A713S	DO27809	MALY	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.6477
p.I711S	DO220891	MELA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.7341
p.L712H	DO222749	MELA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.7313
p.P722S	DO218864	SKCA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1667
p.M707K	SIDM00163	Biliary Tract Carcinoma	GDSC	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.3056
p.M707K	ACH-000461	Bile Duct Cancer	CCLE	PRQGLAPVP	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.3056

Kaplan plot for CDH8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH8

UniProt ID: P55286

Entrez ID: 1006

Protein name: Cadherin-8

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH8 in