DegronMD

Uniprot ID: P55286

Source protein: Cadherin-8

Source gene: CDH8

Class: DEG_APCC_DBOX_1

Location: 708:716

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9744

ASA_SCORE: 57.7

COIL: 0.8287

CONS_SCORE: 0.5721

DSS_SCORE: 0.454

HELIX: 0.0476

FCONS_SCORE: 0.8833

RIG_SCORE: 0.7018

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L704F	TCGA-32-4213	GBM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.2222
p.L704F	DO11483	GBM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.2222
p.D699Y	TCGA-46-3769	LUSC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.0833
p.D699Y	DO26590	LUSC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.0833
p.M707I	TCGA-55-7994	LUAD	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.3056
p.M707I	DO45311	LUAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.3056
p.R709W	TCGA-95-A4VK	LUAD	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.8634
p.D720H	TCGA-98-8021	LUSC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.2222
p.D720H	DO27468	LUSC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.2222
p.V715F	TCGA-A5-A0G2	UCEC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.7068
p.V715F	DO41235	UCEC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.7068
p.D699A	TCGA-A5-A0G2	UCEC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.0833
p.D699A	DO41235	UCEC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.0833
p.G718C	TCGA-BF-A1Q0	SKCM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.2778
p.G718C	DO47374	SKCM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.2778
p.F724C	TCGA-BR-8384	STAD	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.1111
p.F724C	DO47749	STAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.1111
p.K698N	TCGA-BR-8677	STAD	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.1667
p.K698N	DO47759	STAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.1667
p.P716S	TCGA-D3-A1QA	SKCM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.5641
p.P716S	DO222880	MELA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.5641
p.P716S	DO47469	SKCM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.5641
p.D699N	TCGA-D3-A3MV	SKCM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.0833
p.D699N	DO222557	MELA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.0833
p.D699N	DO37727	SKCM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.0833
p.D722N	TCGA-D3-A5GO	SKCM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.1667
p.D722N	DO47419	SKCM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.1667
p.K698R	TCGA-DD-AACC	LIHC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.1667
p.K698R	DO52198	LIHC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.1667
p.P714S	TCGA-EB-A41A	SKCM	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.5641
p.P714S	DO37429	SKCM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.5641
p.R709M	TCGA-EO-A22R	UCEC	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.8632
p.R709M	DO42713	UCEC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.8632
p.Q705P	TCGA-G4-6317	COAD	TCGA	PRQGLAPVP	DEG_APCC_DBOX_1	0.25
p.Q705P	DO10100	COAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.25
p.Q703R	DO228483	BRCA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.1944
p.Q703R	DO234285	ESAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.1944
p.Q703R	DO229346	LAML	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.1944
p.G699D	DO230343	COCA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.0833
p.G699D	DO11854	GBM	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.0833
p.L724P	DO234152	ESAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.1111
p.K712T	DO234442	ESAD	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.7306
p.K698T	DO233137	GACA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.1667
p.P708T	DO229045	LICA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.5919
p.P708T	DO230999	LUSC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.5919
p.P708T	DO224551	LUSC	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.5919
p.P710S	DO50970	LICA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.6752
p.A713S	DO27809	MALY	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.6477
p.I711S	DO220891	MELA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.7341
p.L712H	DO222749	MELA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.7313
p.P722S	DO218864	SKCA	ICGC	PRQGLAPVP	DEG_APCC_DBOX_1	0.1667
p.M707K	SIDM00163	Biliary Tract Carcinoma	GDSC	PRQGLAPVP	DEG_APCC_DBOX_1	0.3056
p.M707K	ACH-000461	Bile Duct Cancer	CCLE	PRQGLAPVP	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRQGLAPVP

Degron related mutations and impact score

Drug responses associated with CDH8 mutations

All proteins holding degron of PRQGLAPVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55286	Cadherin-8	DEG_APCC_DBOX_1	708:716	PRQGLAPVP	APC,CDC20,FZR1	0.9744	More...