DegronMD - P55290(CDH13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G452R	TCGA-19-5959	GBM	TCGA	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.7568
p.G452E	TCGA-3N-A9WD	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.7199
p.T462P	TCGA-56-8504	LUSC	TCGA	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.1111
p.T462A	TCGA-AX-A1CE	UCEC	TCGA	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.1111
p.D436N	TCGA-EE-A2GI	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0833
p.G455R	TCGA-GN-A266	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.3056
p.S435Y	DO44041	BLCA	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0556
p.V464I	DO482	BLCA	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0556
p.V464I	DO34312	PACA	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0556
p.V464I	DO37291	READ	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0556
p.G457S	DO3305	BRCA	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.25
p.G457S	DO48020	STAD	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.25
p.G457S	Calu-3	lung	COSMIC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.25
p.P449S	DO219735	CESC	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.5641
p.P449S	DO42977	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.5641
p.V464G	DO228288	LICA	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0556
p.V451L	DO228948	LICA	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.6765
p.G457C	DO24800	LUAD	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.25
p.S435F	DO222875	MELA	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0556
p.S435F	DO219482	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0556
p.E445K	DO37444	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.7022
p.E447K	DO50291	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.591
p.E447K	DO51301	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.591
p.H438Y	DO51274	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.1389
p.D448G	DO43041	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.6087
p.K443R	DO41578	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.2778
p.N463K	SIDM01203	Other Solid Cancers	GDSC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0833
p.N463K	ACH-002291	Embryonal Cancer	CCLE	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0833
p.N463K	NTERA-2_cl_D1	testis	COSMIC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0833
p.H461Y	SIDM00007	Other Solid Cancers	GDSC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.1389
p.H461Y	ACH-001550	Skin Cancer	CCLE	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.1389
p.H461Y	MCC13	skin	COSMIC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.1389
p.G441C	SIDM01617	Endometrial Carcinoma	GDSC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.2222
p.G441C	ACH-000994	Endometrial/Uterine Cancer	CCLE	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.2222
p.V454I	WM1552C	skin	COSMIC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.5965
p.G435D	SNU-1040	large intestine	COSMIC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.0556

Kaplan plot for CDH13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH13

UniProt ID: P55290

Entrez ID: 1012

Protein name: Cadherin-13 (Heart cadherin) (H-cadherin) (P105) (Truncated cadherin) (T-cad) (T-cadherin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH13 in