DegronMD - P55290(CDH13)

FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. {ECO:0000269|PubMed:10737605}.

GO - Biological processes (BP): calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; endothelial cell migration [GO:0043542]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte p... View more >>

GO - Molecular function (MF): adiponectin binding [GO:0055100]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle binding [GO:0030169]; protein homodimerization activity [GO:0042803]

GO - Cellular component (CC): anchored component of membrane [GO:0031225]; catenin complex [GO:0016342]; caveola [GO:0005901]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrac... View more >>

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
ENEDPLVPDV	DEG_COP1_1	COP1	Cadherin-13	445:454	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G452R	TCGA-19-5959	GBM	TCGA	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.7568
p.G452E	TCGA-3N-A9WD	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.7199
p.E445K	DO37444	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.7022
p.V451L	DO228948	LICA	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.6765
p.D448G	DO43041	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.6087
p.V454I	WM1552C	skin	COSMIC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.5965
p.E447K	DO50291	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.591
p.E447K	DO51301	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.591
p.P449S	DO219735	CESC	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.5641
p.P449S	DO42977	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation altering degron motif	0.5641
p.G455R	TCGA-GN-A266	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.3056
p.K443R	DO41578	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.2778
p.G457S	DO3305	BRCA	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.25
p.G457S	DO48020	STAD	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.25
p.G457S	Calu-3	lung	COSMIC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.25
p.G457C	DO24800	LUAD	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.25
p.G441C	SIDM01617	Endometrial Carcinoma	GDSC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.2222
p.G441C	ACH-000994	Endometrial/Uterine Cancer	CCLE	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.2222
p.H438Y	DO51274	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.1389
p.H461Y	SIDM00007	Other Solid Cancers	GDSC	ENEDPLVPDV	DEG_COP1_1	445:454	Mutation rewiring degron network	0.1389

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No resistance data available for this Degron.

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH13

UniProt ID: P55290

Entrez ID: 1012

Protein name: Cadherin-13 (Heart cadherin) (H-cadherin) (P105) (Truncated cadherin) (T-cad) (T-cadherin)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for CDH13 in