DegronMD

Uniprot ID: P55290

Source protein: Cadherin-13

Source gene: CDH13

Class: DEG_COP1_1

Location: 445:454

E3 ligase: COP1

DEGRON score: 0.9137

ASA_SCORE: 67.47

COIL: 0.7565

CONS_SCORE: 0.5403

DSS_SCORE: 0.3122

HELIX: 0.0247

FCONS_SCORE: 0.8938

RIG_SCORE: 0.7956

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G452R	TCGA-19-5959	GBM	TCGA	ENEDPLVPDV	DEG_COP1_1	0.7568
p.G452E	TCGA-3N-A9WD	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	0.7199
p.T462P	TCGA-56-8504	LUSC	TCGA	ENEDPLVPDV	DEG_COP1_1	0.1111
p.T462A	TCGA-AX-A1CE	UCEC	TCGA	ENEDPLVPDV	DEG_COP1_1	0.1111
p.D436N	TCGA-EE-A2GI	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	0.0833
p.G455R	TCGA-GN-A266	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	0.3056
p.S435Y	DO44041	BLCA	ICGC	ENEDPLVPDV	DEG_COP1_1	0.0556
p.V464I	DO482	BLCA	ICGC	ENEDPLVPDV	DEG_COP1_1	0.0556
p.V464I	DO34312	PACA	ICGC	ENEDPLVPDV	DEG_COP1_1	0.0556
p.V464I	DO37291	READ	ICGC	ENEDPLVPDV	DEG_COP1_1	0.0556
p.G457S	DO3305	BRCA	ICGC	ENEDPLVPDV	DEG_COP1_1	0.25
p.G457S	DO48020	STAD	ICGC	ENEDPLVPDV	DEG_COP1_1	0.25
p.G457S	Calu-3	lung	COSMIC	ENEDPLVPDV	DEG_COP1_1	0.25
p.P449S	DO219735	CESC	ICGC	ENEDPLVPDV	DEG_COP1_1	0.5641
p.P449S	DO42977	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	0.5641
p.V464G	DO228288	LICA	ICGC	ENEDPLVPDV	DEG_COP1_1	0.0556
p.V451L	DO228948	LICA	ICGC	ENEDPLVPDV	DEG_COP1_1	0.6765
p.G457C	DO24800	LUAD	ICGC	ENEDPLVPDV	DEG_COP1_1	0.25
p.S435F	DO222875	MELA	ICGC	ENEDPLVPDV	DEG_COP1_1	0.0556
p.S435F	DO219482	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	0.0556
p.E445K	DO37444	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	0.7022
p.E447K	DO50291	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	0.591
p.E447K	DO51301	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	0.591
p.H438Y	DO51274	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	0.1389
p.D448G	DO43041	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	0.6087
p.K443R	DO41578	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	0.2778
p.N463K	SIDM01203	Other Solid Cancers	GDSC	ENEDPLVPDV	DEG_COP1_1	0.0833
p.N463K	ACH-002291	Embryonal Cancer	CCLE	ENEDPLVPDV	DEG_COP1_1	0.0833
p.N463K	NTERA-2_cl_D1	testis	COSMIC	ENEDPLVPDV	DEG_COP1_1	0.0833
p.H461Y	SIDM00007	Other Solid Cancers	GDSC	ENEDPLVPDV	DEG_COP1_1	0.1389
p.H461Y	ACH-001550	Skin Cancer	CCLE	ENEDPLVPDV	DEG_COP1_1	0.1389
p.H461Y	MCC13	skin	COSMIC	ENEDPLVPDV	DEG_COP1_1	0.1389
p.G441C	SIDM01617	Endometrial Carcinoma	GDSC	ENEDPLVPDV	DEG_COP1_1	0.2222
p.G441C	ACH-000994	Endometrial/Uterine Cancer	CCLE	ENEDPLVPDV	DEG_COP1_1	0.2222
p.V454I	WM1552C	skin	COSMIC	ENEDPLVPDV	DEG_COP1_1	0.5965
p.G435D	SNU-1040	large_intestine	COSMIC	ENEDPLVPDV	DEG_COP1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ENEDPLVPDV

Degron related mutations and impact score

Drug responses associated with CDH13 mutations

All proteins holding degron of ENEDPLVPDV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55290	Cadherin-13	DEG_COP1_1	445:454	ENEDPLVPDV	COP1	0.9137	More...