DegronMD

Uniprot ID: P55290

Source protein: Cadherin-13

Source gene: CDH13

Class: DEG_COP1_1

Location: 445:454

E3 ligase: COP1

DEGRON score: 0.9137

ASA_SCORE: 67.47

COIL: 0.7565

CONS_SCORE: 0.5403

DSS_SCORE: 0.3122

HELIX: 0.0247

FCONS_SCORE: 0.8938

RIG_SCORE: 0.7956

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G452R	TCGA-19-5959	GBM	TCGA	ENEDPLVPDV	DEG_COP1_1	0.7568
p.G452E	TCGA-3N-A9WD	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	0.7199
p.E445K	DO37444	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	0.7022
p.V451L	DO228948	LICA	ICGC	ENEDPLVPDV	DEG_COP1_1	0.6765
p.D448G	DO43041	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	0.6087
p.V454I	WM1552C	skin	COSMIC	ENEDPLVPDV	DEG_COP1_1	0.5965
p.E447K	DO50291	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	0.591
p.E447K	DO51301	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	0.591
p.P449S	DO219735	CESC	ICGC	ENEDPLVPDV	DEG_COP1_1	0.5641
p.P449S	DO42977	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	0.5641
p.G455R	TCGA-GN-A266	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	0.3056
p.K443R	DO41578	UCEC	ICGC	ENEDPLVPDV	DEG_COP1_1	0.2778
p.G457S	DO3305	BRCA	ICGC	ENEDPLVPDV	DEG_COP1_1	0.25
p.G457S	DO48020	STAD	ICGC	ENEDPLVPDV	DEG_COP1_1	0.25
p.G457S	Calu-3	lung	COSMIC	ENEDPLVPDV	DEG_COP1_1	0.25
p.G457C	DO24800	LUAD	ICGC	ENEDPLVPDV	DEG_COP1_1	0.25
p.G441C	SIDM01617	Endometrial Carcinoma	GDSC	ENEDPLVPDV	DEG_COP1_1	0.2222
p.G441C	ACH-000994	Endometrial/Uterine Cancer	CCLE	ENEDPLVPDV	DEG_COP1_1	0.2222
p.H438Y	DO51274	SKCM	ICGC	ENEDPLVPDV	DEG_COP1_1	0.1389
p.H461Y	SIDM00007	Other Solid Cancers	GDSC	ENEDPLVPDV	DEG_COP1_1	0.1389
p.H461Y	ACH-001550	Skin Cancer	CCLE	ENEDPLVPDV	DEG_COP1_1	0.1389
p.H461Y	MCC13	skin	COSMIC	ENEDPLVPDV	DEG_COP1_1	0.1389
p.T462P	TCGA-56-8504	LUSC	TCGA	ENEDPLVPDV	DEG_COP1_1	0.1111
p.T462A	TCGA-AX-A1CE	UCEC	TCGA	ENEDPLVPDV	DEG_COP1_1	0.1111
p.D436N	TCGA-EE-A2GI	SKCM	TCGA	ENEDPLVPDV	DEG_COP1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55290	Cadherin-13	DEG_COP1_1	445:454	ENEDPLVPDV	COP1	0.9137	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons