DegronMD - P55327(TPD52)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S72L	TCGA-AX-A05S	UCEC	TCGA	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.E82Q	TCGA-BA-5152	HNSC	TCGA	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.5633
p.E82Q	DO14393	HNSC	ICGC	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.5633
p.Q95E	TCGA-C8-A1HM	BRCA	TCGA	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1111
p.Q95E	DO3904	BRCA	ICGC	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1111
p.Q91K	TCGA-DA-A1IB	SKCM	TCGA	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.2222
p.Q91K	DO38033	SKCM	ICGC	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.2222
p.L97I	DO234389	ESAD	ICGC	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.0556
p.A84G	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.6429
p.A84G	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.6429
p.E73K	SIDM01561	Melanoma	GDSC	LRRELAKVE	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons