DegronMD

Uniprot ID: P55327

Source protein: Tumor protein D52

Source gene: TPD52

Class: DEG_APCC_DBOX_1

Location: 79:87

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8303

ASA_SCORE: 78.6333

COIL: 0.0481

CONS_SCORE: 0.7172

DSS_SCORE: 0.4337

HELIX: 0.9512

FCONS_SCORE: 1.1633

RIG_SCORE: 0.7969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S72L	TCGA-AX-A05S	UCEC	TCGA	LRRELAKVE	DEG_APCC_DBOX_1	0.1389
p.E82Q	TCGA-BA-5152	HNSC	TCGA	LRRELAKVE	DEG_APCC_DBOX_1	0.5633
p.E82Q	DO14393	HNSC	ICGC	LRRELAKVE	DEG_APCC_DBOX_1	0.5633
p.Q95E	TCGA-C8-A1HM	BRCA	TCGA	LRRELAKVE	DEG_APCC_DBOX_1	0.1111
p.Q95E	DO3904	BRCA	ICGC	LRRELAKVE	DEG_APCC_DBOX_1	0.1111
p.Q91K	TCGA-DA-A1IB	SKCM	TCGA	LRRELAKVE	DEG_APCC_DBOX_1	0.2222
p.Q91K	DO38033	SKCM	ICGC	LRRELAKVE	DEG_APCC_DBOX_1	0.2222
p.L97I	DO234389	ESAD	ICGC	LRRELAKVE	DEG_APCC_DBOX_1	0.0556
p.A84G	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRRELAKVE	DEG_APCC_DBOX_1	0.6429
p.A84G	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRRELAKVE	DEG_APCC_DBOX_1	0.6429
p.E73K	SIDM01561	Melanoma	GDSC	LRRELAKVE	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55327	Tumor protein D52	DEG_APCC_DBOX_1	79:87	LRRELAKVE	APC,CDC20,FZR1	0.8303	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons