DegronMD - P56199(ITGA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1040N	TCGA-55-7573	LUAD	TCGA	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.25
p.S1040N	DO23675	LUAD	ICGC	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.25
p.S1043Y	TCGA-EO-A3AY	UCEC	TCGA	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.1667
p.S1043Y	DO43202	UCEC	ICGC	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.1667
p.G1044E	TCGA-FR-A726	SKCM	TCGA	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.1389
p.G1044E	DO48665	SKCM	ICGC	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.1389
p.A1028V	TCGA-HZ-A49I	PAAD	TCGA	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.25
p.A1028V	DO32790	PAAD	ICGC	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.25
p.P1038S	DO220856	MELA	ICGC	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.3056
p.E1036K	SIDM00608	Plasma Cell Myeloma	GDSC	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation altering degron motif	0.591
p.E1036K	ACH-000714	Myeloma	CCLE	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation altering degron motif	0.591
p.E1036K	KMS-11	haematopoietic and lymphoid tissue	COSMIC	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation altering degron motif	0.591
p.K1045N	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation substituting flanking lysine	0.2222
p.K1045N	ACH-000875	Lung Cancer	CCLE	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation substituting flanking lysine	0.2222
p.K1045N	NCI-H2347	lung	COSMIC	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation substituting flanking lysine	0.2222
p.S1040R	SIDM01588	Endometrial Carcinoma	GDSC	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.25
p.S1040R	ACH-000993	Endometrial/Uterine Cancer	CCLE	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation rewiring degron network	0.25
p.E1036Q	ACH-000575	Lung Cancer	CCLE	RPHIFED	LIG_APCC_ABBAyCdc20_2	1031:1037	Mutation altering degron motif	0.5633

Kaplan plot for ITGA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGA1

UniProt ID: P56199

Entrez ID: 3672

Protein name: Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITGA1 in