DegronMD

Uniprot ID: P56199

Source protein: Integrin alpha-1

Source gene: ITGA1

Class: LIG_APCC_ABBAyCdc20_2

Location: 1031:1037

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7603

ASA_SCORE: 70.2857

COIL: 0.676

CONS_SCORE: 0.3973

DSS_SCORE: 0.4024

HELIX: 0.085

FCONS_SCORE: 0.7625

RIG_SCORE: 0.7862

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1040N	TCGA-55-7573	LUAD	TCGA	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.25
p.S1040N	DO23675	LUAD	ICGC	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.25
p.S1043Y	TCGA-EO-A3AY	UCEC	TCGA	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.1667
p.S1043Y	DO43202	UCEC	ICGC	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.1667
p.G1044E	TCGA-FR-A726	SKCM	TCGA	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1044E	DO48665	SKCM	ICGC	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.A1028V	TCGA-HZ-A49I	PAAD	TCGA	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.25
p.A1028V	DO32790	PAAD	ICGC	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.25
p.P1038S	DO220856	MELA	ICGC	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.E1036K	SIDM00608	Plasma Cell Myeloma	GDSC	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.591
p.E1036K	ACH-000714	Myeloma	CCLE	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.591
p.E1036K	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.591
p.K1045N	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.2222
p.K1045N	ACH-000875	Lung Cancer	CCLE	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.2222
p.K1045N	NCI-H2347	lung	COSMIC	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.2222
p.S1040R	SIDM01588	Endometrial Carcinoma	GDSC	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.25
p.S1040R	ACH-000993	Endometrial/Uterine Cancer	CCLE	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.25
p.E1036Q	ACH-000575	Lung Cancer	CCLE	RPHIFED	LIG_APCC_ABBAyCdc20_2	0.5633

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56199	Integrin alpha-1	LIG_APCC_ABBAyCdc20_2	1031:1037	RPHIFED	APC,CDC20,FZR1	0.7603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons