DegronMD - P56373(P2RX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S390L	TCGA-19-5956	GBM	TCGA	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.7667
p.S390L	TCGA-3N-A9WD	SKCM	TCGA	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.7667
p.S390L	TCGA-DD-AAC9	LIHC	TCGA	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.7667
p.S390L	DO222884	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.7667
p.S390L	DO13863	GBM	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.7667
p.S390L	DO52194	LIHC	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.7667
p.S390L	DO51235	SKCM	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.7667
p.D389N	TCGA-A5-A2K5	UCEC	TCGA	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.6932
p.D389N	TCGA-AP-A1DV	UCEC	TCGA	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.6932
p.D389N	DO43186	UCEC	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.6932
p.D389N	DO41379	UCEC	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.6932
p.D389N	SIDM00193	Colorectal Carcinoma	GDSC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.6932
p.D389N	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.6932
p.D389N	SNU-81	large intestine	COSMIC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.6932
p.F393L	TCGA-DD-A3A6	LIHC	TCGA	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.587
p.F393L	DO44875	LIHC	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.587
p.D379N	TCGA-FS-A1ZK	SKCM	TCGA	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.0556
p.D379N	DO37474	SKCM	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.0556
p.A383V	DO230334	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667
p.A383V	DO229010	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667
p.A383V	DO229013	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667
p.A383V	DO229016	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667
p.A383V	DO229003	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667
p.A383V	DO229005	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667
p.A383V	DO229480	LAML	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667
p.A383V	DO228947	LICA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.1667
p.D379Y	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.0556
p.D379Y	ACH-000718	Lung Cancer	CCLE	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.0556
p.D379Y	NCI-H2291	lung	COSMIC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.0556
p.T388S	SIDM00643	Non-Cancerous	GDSC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.3056
p.T388S	ACH-002363	Non-Cancerous	CCLE	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.3056
p.I395M	SIDM01752	Pancreatic Carcinoma	GDSC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.3056
p.I395M	ACH-000685	Pancreatic Cancer	CCLE	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.3056
p.D389Y	SIDM01473	Plasma Cell Myeloma	GDSC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.7325
p.D389Y	ACH-000541	Myeloma	CCLE	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation altering degron motif	0.7325
p.D388N	SNU-81	large intestine	COSMIC	DSGAFS	DEG_SCF_TRCP1_1	389:394	Mutation rewiring degron network	0.3056

Kaplan plot for P2RX3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

P2RX3

UniProt ID: P56373

Entrez ID: 5024

Protein name: P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for P2RX3 in