DegronMD

Uniprot ID: P56373

Source protein: P2X purinoceptor 3

Source gene: P2RX3

Class: DEG_SCF_TRCP1_1

Location: 389:394

E3 ligase: BTRC

DEGRON score: 0.8621

ASA_SCORE: 84.6333

COIL: 0.9258

CONS_SCORE: 0.3567

DSS_SCORE: 0.7547

HELIX: 0.0475

FCONS_SCORE: 0.9878

RIG_SCORE: 0.6581

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S390L	TCGA-19-5956	GBM	TCGA	DSGAFS	DEG_SCF_TRCP1_1	0.7667
p.S390L	TCGA-3N-A9WD	SKCM	TCGA	DSGAFS	DEG_SCF_TRCP1_1	0.7667
p.S390L	TCGA-DD-AAC9	LIHC	TCGA	DSGAFS	DEG_SCF_TRCP1_1	0.7667
p.S390L	DO222884	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.7667
p.S390L	DO13863	GBM	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.7667
p.S390L	DO52194	LIHC	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.7667
p.S390L	DO51235	SKCM	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.7667
p.D389N	TCGA-A5-A2K5	UCEC	TCGA	DSGAFS	DEG_SCF_TRCP1_1	0.6932
p.D389N	TCGA-AP-A1DV	UCEC	TCGA	DSGAFS	DEG_SCF_TRCP1_1	0.6932
p.D389N	DO43186	UCEC	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.6932
p.D389N	DO41379	UCEC	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.6932
p.D389N	SIDM00193	Colorectal Carcinoma	GDSC	DSGAFS	DEG_SCF_TRCP1_1	0.6932
p.D389N	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGAFS	DEG_SCF_TRCP1_1	0.6932
p.D389N	SNU-81	large_intestine	COSMIC	DSGAFS	DEG_SCF_TRCP1_1	0.6932
p.F393L	TCGA-DD-A3A6	LIHC	TCGA	DSGAFS	DEG_SCF_TRCP1_1	0.587
p.F393L	DO44875	LIHC	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.587
p.D379N	TCGA-FS-A1ZK	SKCM	TCGA	DSGAFS	DEG_SCF_TRCP1_1	0.0556
p.D379N	DO37474	SKCM	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.0556
p.A383V	DO230334	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.1667
p.A383V	DO229010	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.1667
p.A383V	DO229013	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.1667
p.A383V	DO229016	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.1667
p.A383V	DO229003	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.1667
p.A383V	DO229005	COCA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.1667
p.A383V	DO229480	LAML	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.1667
p.A383V	DO228947	LICA	ICGC	DSGAFS	DEG_SCF_TRCP1_1	0.1667
p.D379Y	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	DSGAFS	DEG_SCF_TRCP1_1	0.0556
p.D379Y	ACH-000718	Lung Cancer	CCLE	DSGAFS	DEG_SCF_TRCP1_1	0.0556
p.D379Y	NCI-H2291	lung	COSMIC	DSGAFS	DEG_SCF_TRCP1_1	0.0556
p.T388S	SIDM00643	Non-Cancerous	GDSC	DSGAFS	DEG_SCF_TRCP1_1	0.3056
p.T388S	ACH-002363	Non-Cancerous	CCLE	DSGAFS	DEG_SCF_TRCP1_1	0.3056
p.I395M	SIDM01752	Pancreatic Carcinoma	GDSC	DSGAFS	DEG_SCF_TRCP1_1	0.3056
p.I395M	ACH-000685	Pancreatic Cancer	CCLE	DSGAFS	DEG_SCF_TRCP1_1	0.3056
p.D389Y	SIDM01473	Plasma Cell Myeloma	GDSC	DSGAFS	DEG_SCF_TRCP1_1	0.7325
p.D389Y	ACH-000541	Myeloma	CCLE	DSGAFS	DEG_SCF_TRCP1_1	0.7325
p.D388N	SNU-81	large_intestine	COSMIC	DSGAFS	DEG_SCF_TRCP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGAFS

Degron related mutations and impact score

Drug responses associated with P2RX3 mutations

All proteins holding degron of DSGAFS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56373	P2X purinoceptor 3	DEG_SCF_TRCP1_1	389:394	DSGAFS	BTRC	0.8621	More...