DegronMD - P56524(HDAC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q383P	TCGA-24-1422	OV	TCGA	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0556
p.R404L	TCGA-90-7964	LUSC	TCGA	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1667
p.R404L	TCGA-DZ-6132	KIRP	TCGA	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1667
p.R404W	TCGA-A5-A1OH	UCEC	TCGA	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1667
p.G390S	TCGA-AC-A8OP	BRCA	TCGA	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.G390S	SIDM00619	Thyroid Gland Carcinoma	GDSC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.G390S	SIDM00612	Glioma	GDSC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.L385F	TCGA-DD-A4NF	LIHC	TCGA	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.G407V	TCGA-EE-A2MG	SKCM	TCGA	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.A388V	DO8898	COAD	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1944
p.L408I	DO229018	LICA	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0556
p.Q395K	DO229032	LICA	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.6944
p.E390D	DO229051	LICA	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.G385V	DO24900	LUAD	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.G385V	DO37651	SKCM	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.L408V	DO45476	LUSC	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0556
p.P393L	DO37619	SKCM	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.7582
p.P392S	DO229257	THCA	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.3056
p.Q391K	DO229227	THCA	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation blocking phosphorylation signal	0.7222
p.P393S	DO223286	UCEC	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.6752
p.S401Y	DO41644	UCEC	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.L404I	DO41488	UCEC	ICGC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1667
p.S400L	SIDM01055	Glioblastoma	GDSC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation blocking phosphorylation signal	0.7222
p.S400L	GAMG	central nervous system	COSMIC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation blocking phosphorylation signal	0.7222
p.S400R	EFM-19	breast	COSMIC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation blocking phosphorylation signal	0.7222
p.A403V	UM-UC-3	urinary tract	COSMIC	LTPYLS	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1944

Kaplan plot for HDAC4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HDAC4

UniProt ID: P56524

Entrez ID: 9759

Protein name: Histone deacetylase 4 (HD4) (EC 3.5.1.98)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HDAC4 in