DegronMD - P56555(DSCR4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T67M	TCGA-2J-AABO	PAAD	TCGA	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation rewiring degron network	0.3056
p.T67M	DO51666	PAAD	ICGC	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation rewiring degron network	0.3056
p.P63T	TCGA-90-A59Q	LUSC	TCGA	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation rewiring degron network	0.1944
p.P63T	DO50103	LUSC	ICGC	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation rewiring degron network	0.1944
p.E80K	TCGA-D9-A1JW	SKCM	TCGA	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation rewiring degron network	0.1389
p.E80K	DO37786	SKCM	ICGC	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation rewiring degron network	0.1389
p.D79N	DO220872	MELA	ICGC	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation rewiring degron network	0.1667
p.G70E	DO220890	MELA	ICGC	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation altering degron motif	0.7199
p.D68V	DO33077	PACA	ICGC	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation altering degron motif	0.7785
p.A72T	ACH-000434	Lung Cancer	CCLE	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation altering degron motif	0.6028
p.S69Y	ACH-000860	Lung Cancer	CCLE	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation altering degron motif	0.712
p.D68A	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGLAS	DEG_SCF_TRCP1_1	68:73	Mutation altering degron motif	0.7793

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons