DegronMD

Uniprot ID: P56555

Source protein: Down syndrome critical region protein 4

Source gene: DSCR4

Class: DEG_SCF_TRCP1_1

Location: 68:73

E3 ligase: BTRC

DEGRON score: 0.7401

ASA_SCORE: 58.2833

COIL: 0.8362

CONS_SCORE: 1

DSS_SCORE: 0.3162

HELIX: 0.0692

FCONS_SCORE: 1

RIG_SCORE: 0.7209

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T67M	TCGA-2J-AABO	PAAD	TCGA	DSGLAS	DEG_SCF_TRCP1_1	0.3056
p.T67M	DO51666	PAAD	ICGC	DSGLAS	DEG_SCF_TRCP1_1	0.3056
p.P63T	TCGA-90-A59Q	LUSC	TCGA	DSGLAS	DEG_SCF_TRCP1_1	0.1944
p.P63T	DO50103	LUSC	ICGC	DSGLAS	DEG_SCF_TRCP1_1	0.1944
p.E80K	TCGA-D9-A1JW	SKCM	TCGA	DSGLAS	DEG_SCF_TRCP1_1	0.1389
p.E80K	DO37786	SKCM	ICGC	DSGLAS	DEG_SCF_TRCP1_1	0.1389
p.D79N	DO220872	MELA	ICGC	DSGLAS	DEG_SCF_TRCP1_1	0.1667
p.G70E	DO220890	MELA	ICGC	DSGLAS	DEG_SCF_TRCP1_1	0.7199
p.D68V	DO33077	PACA	ICGC	DSGLAS	DEG_SCF_TRCP1_1	0.7785
p.A72T	ACH-000434	Lung Cancer	CCLE	DSGLAS	DEG_SCF_TRCP1_1	0.6028
p.S69Y	ACH-000860	Lung Cancer	CCLE	DSGLAS	DEG_SCF_TRCP1_1	0.712
p.D68A	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGLAS	DEG_SCF_TRCP1_1	0.7793

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56555	Down syndrome critical region protein 4	DEG_SCF_TRCP1_1	68:73	DSGLAS	BTRC	0.7401	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons