DegronMD - P56749(CLDN12)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M217I	TCGA-22-5491	LUSC	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.0833
p.M217I	DO26420	LUSC	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.0833
p.R229S	TCGA-AP-A0LP	UCEC	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.6316
p.R229S	DO43146	UCEC	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.6316
p.S231F	TCGA-BR-6705	STAD	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7982
p.S231F	DO38835	STAD	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7982
p.S228F	TCGA-G9-6363	PRAD	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7982
p.S228F	DO36278	PRAD	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7982
p.I235V	TCGA-HU-A4H0	STAD	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.3056
p.I235V	DO50793	LIRI	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.3056
p.I235V	DO47785	STAD	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.3056
p.S241L	TCGA-P3-A5QF	HNSC	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.S241L	DO44439	HNSC	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.S241L	SIDM01776	Plasma Cell Myeloma	GDSC	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.S241L	ACH-001162	Myeloma	CCLE	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.P223S	DO50339	ESAD	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.25

Kaplan plot for CLDN12 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLDN12

UniProt ID: P56749

Entrez ID: 9069

Protein name: Claudin-12

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CLDN12 in