DegronMD

Uniprot ID: P56749

Source protein: Claudin-12

Source gene: CLDN12

Class: DEG_APCC_DBOX_1

Location: 226:234

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5594

ASA_SCORE: 104.8222

COIL: 0.8151

CONS_SCORE: 0.8695

DSS_SCORE: 0.2645

HELIX: 0.0599

FCONS_SCORE: 1.2227

RIG_SCORE: 0.7393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M217I	TCGA-22-5491	LUSC	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	0.0833
p.M217I	DO26420	LUSC	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	0.0833
p.R229S	TCGA-AP-A0LP	UCEC	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	0.6316
p.R229S	DO43146	UCEC	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	0.6316
p.S231F	TCGA-BR-6705	STAD	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	0.7982
p.S231F	DO38835	STAD	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	0.7982
p.S228F	TCGA-G9-6363	PRAD	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	0.7982
p.S228F	DO36278	PRAD	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	0.7982
p.I235V	TCGA-HU-A4H0	STAD	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	0.3056
p.I235V	DO50793	LIRI	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	0.3056
p.I235V	DO47785	STAD	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	0.3056
p.S241L	TCGA-P3-A5QF	HNSC	TCGA	ARSRLSAIE	DEG_APCC_DBOX_1	0.1389
p.S241L	DO44439	HNSC	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	0.1389
p.S241L	SIDM01776	Plasma Cell Myeloma	GDSC	ARSRLSAIE	DEG_APCC_DBOX_1	0.1389
p.S241L	ACH-001162	Myeloma	CCLE	ARSRLSAIE	DEG_APCC_DBOX_1	0.1389
p.P223S	DO50339	ESAD	ICGC	ARSRLSAIE	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56749	Claudin-12	DEG_APCC_DBOX_1	226:234	ARSRLSAIE	APC,CDC20,FZR1	0.5594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons