DegronMD - P57060(RWDD2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F282L	TCGA-38-4628	LUAD	TCGA	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.25
p.F282L	DO26354	LUAD	ICGC	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.25
p.F282L	SIDM00534	Colorectal Carcinoma	GDSC	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.25
p.F282L	ACH-000986	Colon/Colorectal Cancer	CCLE	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.25
p.F282L	HT-115	large intestine	COSMIC	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.25
p.G289R	TCGA-AA-3715	COAD	TCGA	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.0556
p.G289R	DO8018	COAD	ICGC	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.0556
p.T268M	TCGA-AP-A1DK	UCEC	TCGA	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.1667
p.T268M	DO42033	UCEC	ICGC	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.1667
p.T268M	ACH-002011	Eye Cancer	CCLE	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.1667
p.G286R	DO222976	BTCA	ICGC	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.1389
p.K280E	DO234322	ESAD	ICGC	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.3056
p.T264K	DO228974	LICA	ICGC	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.0556
p.R288G	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.0833
p.A287G	ACH-001551	Skin Cancer	CCLE	FSIFEE	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons