DegronMD

Uniprot ID: P57060

Source protein: RWD domain-containing protein 2B

Source gene: RWDD2B

Class: LIG_APCC_ABBA_1

Location: 274:279

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6561

ASA_SCORE: 57.85

COIL: 0.4707

CONS_SCORE: 0.4997

DSS_SCORE: 0.288

HELIX: 0.0263

FCONS_SCORE: 1.2696

RIG_SCORE: 0.8453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F282L	TCGA-38-4628	LUAD	TCGA	FSIFEE	LIG_APCC_ABBA_1	0.25
p.F282L	DO26354	LUAD	ICGC	FSIFEE	LIG_APCC_ABBA_1	0.25
p.F282L	SIDM00534	Colorectal Carcinoma	GDSC	FSIFEE	LIG_APCC_ABBA_1	0.25
p.F282L	ACH-000986	Colon/Colorectal Cancer	CCLE	FSIFEE	LIG_APCC_ABBA_1	0.25
p.F282L	HT-115	large_intestine	COSMIC	FSIFEE	LIG_APCC_ABBA_1	0.25
p.G289R	TCGA-AA-3715	COAD	TCGA	FSIFEE	LIG_APCC_ABBA_1	0.0556
p.G289R	DO8018	COAD	ICGC	FSIFEE	LIG_APCC_ABBA_1	0.0556
p.T268M	TCGA-AP-A1DK	UCEC	TCGA	FSIFEE	LIG_APCC_ABBA_1	0.1667
p.T268M	DO42033	UCEC	ICGC	FSIFEE	LIG_APCC_ABBA_1	0.1667
p.T268M	ACH-002011	Eye Cancer	CCLE	FSIFEE	LIG_APCC_ABBA_1	0.1667
p.G286R	DO222976	BTCA	ICGC	FSIFEE	LIG_APCC_ABBA_1	0.1389
p.K280E	DO234322	ESAD	ICGC	FSIFEE	LIG_APCC_ABBA_1	0.3056
p.T264K	DO228974	LICA	ICGC	FSIFEE	LIG_APCC_ABBA_1	0.0556
p.R288G	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	FSIFEE	LIG_APCC_ABBA_1	0.0833
p.A287G	ACH-001551	Skin Cancer	CCLE	FSIFEE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P57060	RWD domain-containing protein 2B	LIG_APCC_ABBA_1	274:279	FSIFEE	APC,CDC20,FZR1	0.6561	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons