DegronMD - P57771(RGS8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G30E	TCGA-18-3409	LUSC	TCGA	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0833
p.G30E	SIDM00179	Melanoma	GDSC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0833
p.G30E	MZ2-MEL	skin	COSMIC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0833
p.Q19H	TCGA-55-7576	LUAD	TCGA	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.7582
p.D17E	TCGA-D8-A1JP	BRCA	TCGA	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.6758
p.D17E	DO5857	BRCA	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.6758
p.R26I	TCGA-GS-A9TW	DLBC	TCGA	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.R26I	DO219915	DLBC	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.R26I	SIDM01205	Acute Myeloid Leukemia	GDSC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.R26I	SIDM01195	Acute Myeloid Leukemia	GDSC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.R26I	TUR	haematopoietic and lymphoid tissue	COSMIC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.G18R	DO219755	CESC	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.6457
p.R8C	DO10132	COAD	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.R8C	DO42504	UCEC	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.L5S	DO230309	COCA	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1111
p.G12R	DO227657	COCA	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.3056
p.C19F	DO233136	GACA	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.5996
p.S8R	DO228976	LICA	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.L5M	DO229026	LICA	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1111
p.P13T	DO229026	LICA	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.7031
p.L5F	DO45237	LIRI	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1111
p.G12E	DO26444	LUSC	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.3056
p.G12E	ACH-002165	Skin Cancer	CCLE	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.3056
p.G12E	MZ2-MEL	skin	COSMIC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.3056
p.K11I	DO222843	MELA	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778
p.R8H	DO36759	READ	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.R8H	SIDM02026	Colorectal Carcinoma	GDSC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.D29N	DO51276	SKCM	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1111
p.D25Y	DO41235	UCEC	ICGC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2222
p.G24D	SIDM00242	Osteosarcoma	GDSC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.25
p.G24D	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.25
p.H22Q	ACH-001329	Brain Cancer	CCLE	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.3056
p.K23Q	ACH-002680	Brain Cancer	CCLE	MRTRLGCLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778

Kaplan plot for RGS8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS8

UniProt ID: P57771

Entrez ID: 85397

Protein name: Regulator of G-protein signaling 8 (RGS8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGS8 in