DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
MRTRLGCLS
Uniprot ID:
P57771
Source protein:
Regulator of G-protein signaling 8
Source gene:
RGS8
Class:
DEG_APCC_DBOX_1
Location:
13:21
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6271
ASA_SCORE:
54.1222
COIL:
0.4887
CONS_SCORE:
0.5525
DSS_SCORE:
0.4221
HELIX:
0.3191
FCONS_SCORE:
1.0788
RIG_SCORE:
0.7131
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G30E
TCGA-18-3409
LUSC
TCGA
MRTRLGCLS
DEG_APCC_DBOX_1
0.0833
p.G30E
SIDM00179
Melanoma
GDSC
MRTRLGCLS
DEG_APCC_DBOX_1
0.0833
p.G30E
MZ2-MEL
skin
COSMIC
MRTRLGCLS
DEG_APCC_DBOX_1
0.0833
p.Q19H
TCGA-55-7576
LUAD
TCGA
MRTRLGCLS
DEG_APCC_DBOX_1
0.7582
p.D17E
TCGA-D8-A1JP
BRCA
TCGA
MRTRLGCLS
DEG_APCC_DBOX_1
0.6758
p.D17E
DO5857
BRCA
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.6758
p.R26I
TCGA-GS-A9TW
DLBC
TCGA
MRTRLGCLS
DEG_APCC_DBOX_1
0.1944
p.R26I
DO219915
DLBC
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1944
p.R26I
SIDM01205
Acute Myeloid Leukemia
GDSC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1944
p.R26I
SIDM01195
Acute Myeloid Leukemia
GDSC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1944
p.R26I
TUR
haematopoietic_and_lymphoid_tissue
COSMIC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1944
p.G18R
DO219755
CESC
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.6457
p.R8C
DO10132
COAD
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1944
p.R8C
DO42504
UCEC
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1944
p.L5S
DO230309
COCA
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1111
p.G12R
DO227657
COCA
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.3056
p.C19F
DO233136
GACA
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.5996
p.S8R
DO228976
LICA
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1944
p.L5M
DO229026
LICA
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1111
p.P13T
DO229026
LICA
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.7031
p.L5F
DO45237
LIRI
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1111
p.G12E
DO26444
LUSC
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.3056
p.G12E
ACH-002165
Skin Cancer
CCLE
MRTRLGCLS
DEG_APCC_DBOX_1
0.3056
p.G12E
MZ2-MEL
skin
COSMIC
MRTRLGCLS
DEG_APCC_DBOX_1
0.3056
p.K11I
DO222843
MELA
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.2778
p.R8H
DO36759
READ
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1944
p.R8H
SIDM02026
Colorectal Carcinoma
GDSC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1944
p.D29N
DO51276
SKCM
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.1111
p.D25Y
DO41235
UCEC
ICGC
MRTRLGCLS
DEG_APCC_DBOX_1
0.2222
p.G24D
SIDM00242
Osteosarcoma
GDSC
MRTRLGCLS
DEG_APCC_DBOX_1
0.25
p.G24D
SIDM01762
Esophageal Squamous Cell Carcinoma
GDSC
MRTRLGCLS
DEG_APCC_DBOX_1
0.25
p.H22Q
ACH-001329
Brain Cancer
CCLE
MRTRLGCLS
DEG_APCC_DBOX_1
0.3056
p.K23Q
ACH-002680
Brain Cancer
CCLE
MRTRLGCLS
DEG_APCC_DBOX_1
0.2778
Drug responses associated with RGS8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MRTRLGCLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P57771
Regulator of G-protein signaling 8
DEG_APCC_DBOX_1
13:21
MRTRLGCLS
APC,CDC20,FZR1
0.6271
More...