DegronMD - P58499(FAM3B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E201K	TCGA-EE-A2MG	SKCM	TCGA	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.0556
p.E201K	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.0556
p.E201K	ACH-000960	Leukemia	CCLE	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.0556
p.Q203K	TCGA-KQ-A41N	BLCA	TCGA	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.1111
p.N215S	TCGA-VS-A9V0	CESC	TCGA	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.5958
p.N220I	DO52717	CLLE	ICGC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.728
p.M221I	DO234285	ESAD	ICGC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.7618
p.M221I	DO229480	LAML	ICGC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.7618
p.F223L	DO228972	LICA	ICGC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.2778
p.S226I	DO229027	LICA	ICGC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.1944
p.N203S	DO26308	LUAD	ICGC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.1111
p.A206G	DO26427	LUSC	ICGC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation substituting flanking lysine	0.3056
p.A209V	DO48173	UCEC	ICGC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.2778
p.A212V	SIDM01617	Endometrial Carcinoma	GDSC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.5825
p.A212V	ACH-000994	Endometrial/Uterine Cancer	CCLE	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.5825
p.K206M	SIDM01450	Gastric Carcinoma	GDSC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation substituting flanking lysine	0.3056
p.R203K	STS-0421	soft tissue	COSMIC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.1111
p.W211C	HCT-15	large intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.7
p.A216S	COR-L88	lung	COSMIC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.7588
p.S209F	HCC2998	large intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.2778
p.S225F	HCC2998	large intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.2222
p.E217D	SNU-81	large intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.6758
p.G214E	CAL-33	upper aerodigestive tract	COSMIC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.7199
p.E201D	SNU-81	large intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.0556
p.W227C	HCT-15	large intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation rewiring degron network	0.1667
p.R219K	STS-0421	soft tissue	COSMIC	DAKNNRYSGWP	CBL_PTK	211:221	Mutation altering degron motif	0.7237

Kaplan plot for FAM3B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM3B

UniProt ID: P58499

Entrez ID: 54097

Protein name: Protein FAM3B (Cytokine-like protein 2-21) (Pancreatic-derived factor) (PANDER)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM3B in