DegronMD

Uniprot ID: P58499

Source protein: Protein FAM3B

Source gene: FAM3B

Class: CBL_PTK

Location: 211:221

E3 ligase: CBL

DEGRON score: 0.9291

ASA_SCORE: 66.5091

COIL: 0.8047

CONS_SCORE: 0.5595

DSS_SCORE: 0.4206

HELIX: 0.0976

FCONS_SCORE: 1.072

RIG_SCORE: 0.6975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E201K	TCGA-EE-A2MG	SKCM	TCGA	DAKNNRYSGWP	CBL_PTK	0.0556
p.E201K	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DAKNNRYSGWP	CBL_PTK	0.0556
p.E201K	ACH-000960	Leukemia	CCLE	DAKNNRYSGWP	CBL_PTK	0.0556
p.Q203K	TCGA-KQ-A41N	BLCA	TCGA	DAKNNRYSGWP	CBL_PTK	0.1111
p.N215S	TCGA-VS-A9V0	CESC	TCGA	DAKNNRYSGWP	CBL_PTK	0.5958
p.N220I	DO52717	CLLE	ICGC	DAKNNRYSGWP	CBL_PTK	0.728
p.M221I	DO234285	ESAD	ICGC	DAKNNRYSGWP	CBL_PTK	0.7618
p.M221I	DO229480	LAML	ICGC	DAKNNRYSGWP	CBL_PTK	0.7618
p.F223L	DO228972	LICA	ICGC	DAKNNRYSGWP	CBL_PTK	0.2778
p.S226I	DO229027	LICA	ICGC	DAKNNRYSGWP	CBL_PTK	0.1944
p.N203S	DO26308	LUAD	ICGC	DAKNNRYSGWP	CBL_PTK	0.1111
p.A206G	DO26427	LUSC	ICGC	DAKNNRYSGWP	CBL_PTK	0.3056
p.A209V	DO48173	UCEC	ICGC	DAKNNRYSGWP	CBL_PTK	0.2778
p.A212V	SIDM01617	Endometrial Carcinoma	GDSC	DAKNNRYSGWP	CBL_PTK	0.5825
p.A212V	ACH-000994	Endometrial/Uterine Cancer	CCLE	DAKNNRYSGWP	CBL_PTK	0.5825
p.K206M	SIDM01450	Gastric Carcinoma	GDSC	DAKNNRYSGWP	CBL_PTK	0.3056
p.R203K	STS-0421	soft_tissue	COSMIC	DAKNNRYSGWP	CBL_PTK	0.1111
p.W211C	HCT-15	large_intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	0.7
p.A216S	COR-L88	lung	COSMIC	DAKNNRYSGWP	CBL_PTK	0.7588
p.S209F	HCC2998	large_intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	0.2778
p.S225F	HCC2998	large_intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	0.2222
p.E217D	SNU-81	large_intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	0.6758
p.G214E	CAL-33	upper_aerodigestive_tract	COSMIC	DAKNNRYSGWP	CBL_PTK	0.7199
p.E201D	SNU-81	large_intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	0.0556
p.W227C	HCT-15	large_intestine	COSMIC	DAKNNRYSGWP	CBL_PTK	0.1667
p.R219K	STS-0421	soft_tissue	COSMIC	DAKNNRYSGWP	CBL_PTK	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P58499	Protein FAM3B	CBL_PTK	211:221	DAKNNRYSGWP	CBL	0.9291	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DAKNNRYSGWP

Degron related mutations and impact score

Drug responses associated with FAM3B mutations

All proteins holding degron of DAKNNRYSGWP