DegronMD - P59103(DAOA)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R122L	TCGA-55-A492	LUAD	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7316
p.R122L	DO23708	LUAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7316
p.R123S	TCGA-A5-A2K5	UCEC	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7427
p.R123S	DO41379	UCEC	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7427
p.R123S	ACH-000222	Pancreatic Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7427
p.R123S	ACH-000880	Gastric Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7427
p.R122H	TCGA-AX-A1CE	UCEC	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7133
p.R122H	TCGA-FU-A3HZ	CESC	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7133
p.R122H	DO6308	CESC	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7133
p.R122H	DO42280	UCEC	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7133
p.P125S	TCGA-BR-4256	STAD	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5641
p.P125S	DO38743	STAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5641
p.R128L	TCGA-BS-A0UF	UCEC	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7316
p.R128L	DO41488	UCEC	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7316
p.D139G	TCGA-D7-A6EY	STAD	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.0833
p.D139G	DO50118	STAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.0833
p.M129V	TCGA-D8-A140	BRCA	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6097
p.M129V	DO2204	BRCA	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6097
p.R128Q	TCGA-D9-A3Z4	SKCM	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6218
p.R128Q	DO37623	SKCM	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6218
p.R128Q	SIDM01105	Melanoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6218
p.R128Q	ACH-000423	Skin Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6218
p.R128Q	ACH-001982	Metastasis	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6218
p.R128Q	SK-MEL-3	skin	COSMIC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6218
p.N135S	TCGA-DF-A2KN	UCEC	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1944
p.N135S	DO223282	UCEC	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1944
p.T131I	TCGA-EB-A5UL	SKCM	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.3056
p.T131I	DO47601	SKCM	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.3056
p.E112G	DO50341	ESAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.0556
p.E127Q	DO234206	ESAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5633
p.E112A	DO234349	ESAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.0556
p.E112V	DO234313	ESAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.0556
p.E112V	DO229183	NKTL	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.0556
p.Y134N	DO228928	LICA	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.2222
p.C132F	DO50847	LICA	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.2778
p.E127D	DO228338	MALY	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5647
p.E127D	SIDM00948	Burkitt's Lymphoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5647
p.E127D	ACH-002232	Lymphoma	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5647
p.E127D	DG-75	haematopoietic and lymphoid tissue	COSMIC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5647
p.Q136E	SIDM01265	Plasma Cell Myeloma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.Q136E	SIDM01090	Colorectal Carcinoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.Q136E	SIDM00969	Ovarian Carcinoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.Q136E	SIDM00954	Breast Carcinoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.R122C	SIDM00789	Colorectal Carcinoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.719
p.R122C	ACH-000997	Colon/Colorectal Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.719
p.R122C	ACH-001061	Colon/Colorectal Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.719
p.R122C	HCT-15	large intestine	COSMIC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.719
p.A115S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1389
p.A115S	ACH-000917	Esophageal Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1389
p.A115S	TE-4	oesophagus	COSMIC	RRQPLERMW	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DAOA

UniProt ID: P59103

Entrez ID: 267012

Protein name: D-amino acid oxidase activator (Protein G72)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DAOA in