DegronMD

Uniprot ID: P59103

Source protein: D-amino acid oxidase activator

Source gene: DAOA

Class: DEG_APCC_DBOX_1

Location: 122:130

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7238

ASA_SCORE: 72.5667

COIL: 0.403

CONS_SCORE: 1

DSS_SCORE: 0.3457

HELIX: 0.4773

FCONS_SCORE: 1.2569

RIG_SCORE: 0.7985

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R122L	TCGA-55-A492	LUAD	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.7316
p.R122L	DO23708	LUAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.7316
p.R123S	TCGA-A5-A2K5	UCEC	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.7427
p.R123S	DO41379	UCEC	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.7427
p.R123S	ACH-000222	Pancreatic Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	0.7427
p.R123S	ACH-000880	Gastric Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	0.7427
p.R122H	TCGA-AX-A1CE	UCEC	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.7133
p.R122H	TCGA-FU-A3HZ	CESC	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.7133
p.R122H	DO6308	CESC	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.7133
p.R122H	DO42280	UCEC	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.7133
p.P125S	TCGA-BR-4256	STAD	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.5641
p.P125S	DO38743	STAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.5641
p.R128L	TCGA-BS-A0UF	UCEC	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.7316
p.R128L	DO41488	UCEC	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.7316
p.D139G	TCGA-D7-A6EY	STAD	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.0833
p.D139G	DO50118	STAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.0833
p.M129V	TCGA-D8-A140	BRCA	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.6097
p.M129V	DO2204	BRCA	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.6097
p.R128Q	TCGA-D9-A3Z4	SKCM	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.6218
p.R128Q	DO37623	SKCM	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.6218
p.R128Q	SIDM01105	Melanoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	0.6218
p.R128Q	ACH-000423	Skin Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	0.6218
p.R128Q	ACH-001982	Metastasis	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	0.6218
p.R128Q	SK-MEL-3	skin	COSMIC	RRQPLERMW	DEG_APCC_DBOX_1	0.6218
p.N135S	TCGA-DF-A2KN	UCEC	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.1944
p.N135S	DO223282	UCEC	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.1944
p.T131I	TCGA-EB-A5UL	SKCM	TCGA	RRQPLERMW	DEG_APCC_DBOX_1	0.3056
p.T131I	DO47601	SKCM	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.3056
p.E112G	DO50341	ESAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.0556
p.E127Q	DO234206	ESAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.5633
p.E112A	DO234349	ESAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.0556
p.E112V	DO234313	ESAD	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.0556
p.E112V	DO229183	NKTL	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.0556
p.Y134N	DO228928	LICA	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.2222
p.C132F	DO50847	LICA	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.2778
p.E127D	DO228338	MALY	ICGC	RRQPLERMW	DEG_APCC_DBOX_1	0.5647
p.E127D	SIDM00948	Burkitt's Lymphoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	0.5647
p.E127D	ACH-002232	Lymphoma	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	0.5647
p.E127D	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	RRQPLERMW	DEG_APCC_DBOX_1	0.5647
p.Q136E	SIDM01265	Plasma Cell Myeloma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	0.1667
p.Q136E	SIDM01090	Colorectal Carcinoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	0.1667
p.Q136E	SIDM00969	Ovarian Carcinoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	0.1667
p.Q136E	SIDM00954	Breast Carcinoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	0.1667
p.R122C	SIDM00789	Colorectal Carcinoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	0.719
p.R122C	ACH-000997	Colon/Colorectal Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	0.719
p.R122C	ACH-001061	Colon/Colorectal Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	0.719
p.R122C	HCT-15	large_intestine	COSMIC	RRQPLERMW	DEG_APCC_DBOX_1	0.719
p.A115S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	RRQPLERMW	DEG_APCC_DBOX_1	0.1389
p.A115S	ACH-000917	Esophageal Cancer	CCLE	RRQPLERMW	DEG_APCC_DBOX_1	0.1389
p.A115S	TE-4	oesophagus	COSMIC	RRQPLERMW	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRQPLERMW

Degron related mutations and impact score

Drug responses associated with DAOA mutations

All proteins holding degron of RRQPLERMW

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P59103	D-amino acid oxidase activator	DEG_APCC_DBOX_1	122:130	RRQPLERMW	APC,CDC20,FZR1	0.7238	More...