DegronMD - P60468(SEC61B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G8D	TCGA-AA-3984	COAD	TCGA	PGPTPSGT	DEG_SCF_FBW7_1	2:9	Mutation altering degron motif	0.6087
p.G8D	DO9002	COAD	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	2:9	Mutation altering degron motif	0.6087
p.G8A	TCGA-CZ-5454	KIRC	TCGA	PGPTPSGT	DEG_SCF_FBW7_1	2:9	Mutation altering degron motif	0.6429
p.G8A	DO17085	KIRC	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	2:9	Mutation altering degron motif	0.6429
p.P18T	DO234392	ESAD	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	2:9	Mutation rewiring degron network	0.0833
p.F4L	DO37715	SKCM	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	2:9	Mutation altering degron motif	0.6981
p.G15D	DO41871	UCEC	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	2:9	Mutation rewiring degron network	0.1667
p.R3Q	DO42568	UCEC	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	2:9	Mutation altering degron motif	0.7329

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons