DegronMD

Uniprot ID: P60468

Source protein: Protein transport protein Sec61 subunit beta

Source gene: SEC61B

Class: DEG_SCF_FBW7_1

Location: 2:9

E3 ligase: FBXW7

DEGRON score: 0.7395

ASA_SCORE: 88.25

COIL: 0.973

CONS_SCORE: 0.5001

DSS_SCORE: 0.9023

HELIX: 0.0195

FCONS_SCORE: 0.8194

RIG_SCORE: 0.5532

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G8D	TCGA-AA-3984	COAD	TCGA	PGPTPSGT	DEG_SCF_FBW7_1	0.6087
p.G8D	DO9002	COAD	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	0.6087
p.G8A	TCGA-CZ-5454	KIRC	TCGA	PGPTPSGT	DEG_SCF_FBW7_1	0.6429
p.G8A	DO17085	KIRC	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	0.6429
p.P18T	DO234392	ESAD	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	0.0833
p.F4L	DO37715	SKCM	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	0.6981
p.G15D	DO41871	UCEC	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	0.1667
p.R3Q	DO42568	UCEC	ICGC	PGPTPSGT	DEG_SCF_FBW7_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P60468	Protein transport protein Sec61 subunit beta	DEG_SCF_FBW7_1	2:9	PGPTPSGT	FBXW7	0.7395	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons