DegronMD - P60880(SNAP25)

SNAP25

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I44T	TCGA-A5-A0GH	UCEC	TCGA	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.1389
p.I44T	DO43634	UCEC	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.1389
p.S25L	TCGA-AP-A0LM	UCEC	TCGA	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.S25L	DO43306	UCEC	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.S25L	SIDM00938	Breast Carcinoma	GDSC	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.S25L	CAL-148	breast	COSMIC	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.K40T	TCGA-BS-A0UF	UCEC	TCGA	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation blocking ubiquitination signal	0.6944
p.K40T	DO41488	UCEC	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation blocking ubiquitination signal	0.6944
p.A22G	TCGA-D8-A1XQ	BRCA	TCGA	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.1389
p.A22G	DO3095	BRCA	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.1389
p.S28I	TCGA-EO-A3B0	UCEC	TCGA	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation blocking phosphorylation signal	0.75
p.S28I	DO219773	UCEC	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation blocking phosphorylation signal	0.75
p.R30L	DO228952	LICA	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation altering degron motif	0.8428
p.R31C	DO27949	ORCA	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	29:37	Mutation altering degron motif	0.719

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*NOTE: the Kaplan plots were collected from OncoLnc