DegronMD

Uniprot ID: P60880

Source protein: Synaptosomal-associated protein 25

Source gene: SNAP25

Class: DEG_APCC_DBOX_1

Location: 29:37

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.908

ASA_SCORE: 65.7667

COIL: 0.0208

CONS_SCORE: 0.88

DSS_SCORE: 0.4496

HELIX: 0.9788

FCONS_SCORE: 1.0289

RIG_SCORE: 0.7686

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I44T	TCGA-A5-A0GH	UCEC	TCGA	TRRMLQLVE	DEG_APCC_DBOX_1	0.1389
p.I44T	DO43634	UCEC	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	0.1389
p.S25L	TCGA-AP-A0LM	UCEC	TCGA	TRRMLQLVE	DEG_APCC_DBOX_1	0.2222
p.S25L	DO43306	UCEC	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	0.2222
p.S25L	SIDM00938	Breast Carcinoma	GDSC	TRRMLQLVE	DEG_APCC_DBOX_1	0.2222
p.S25L	CAL-148	breast	COSMIC	TRRMLQLVE	DEG_APCC_DBOX_1	0.2222
p.K40T	TCGA-BS-A0UF	UCEC	TCGA	TRRMLQLVE	DEG_APCC_DBOX_1	0.6944
p.K40T	DO41488	UCEC	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	0.6944
p.A22G	TCGA-D8-A1XQ	BRCA	TCGA	TRRMLQLVE	DEG_APCC_DBOX_1	0.1389
p.A22G	DO3095	BRCA	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	0.1389
p.S28I	TCGA-EO-A3B0	UCEC	TCGA	TRRMLQLVE	DEG_APCC_DBOX_1	0.75
p.S28I	DO219773	UCEC	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	0.75
p.R30L	DO228952	LICA	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	0.8428
p.R31C	DO27949	ORCA	ICGC	TRRMLQLVE	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P60880	Synaptosomal-associated protein 25	DEG_APCC_DBOX_1	29:37	TRRMLQLVE	APC,CDC20,FZR1	0.908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons