DegronMD - P61026(RAB10)

FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Plays also a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148). {ECO:0000250|UniProtKB:P24409, ECO:0000250|UniProtKB:P61027, ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164, ECO:0000269|PubMed:23263280, ECO:0000269|PubMed:30398148}.; FUNCTION: (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole. {ECO:0000269|PubMed:31540829}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P175H	TCGA-F7-A624	HNSC	TCGA	LRKTPVKE	DEG_SCF_FBW7_2	171:178	Mutation altering degron motif	0.7694
p.P175H	DO44440	HNSC	ICGC	LRKTPVKE	DEG_SCF_FBW7_2	171:178	Mutation altering degron motif	0.7694
p.S181I	DO229025	LICA	ICGC	LRKTPVKE	DEG_SCF_FBW7_2	171:178	Mutation blocking phosphorylation signal	0.6944
p.S187I	DO229034	LICA	ICGC	LRKTPVKE	DEG_SCF_FBW7_2	171:178	Mutation blocking phosphorylation signal	0.5278
p.D185N	SIDM02029	Colorectal Carcinoma	GDSC	LRKTPVKE	DEG_SCF_FBW7_2	171:178	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAB10

UniProt ID: P61026

Entrez ID: 10890

Protein name: Ras-related protein Rab-10 (EC 3.6.5.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAB10 in