DegronMD

Uniprot ID: P61026

Source protein: Ras-related protein Rab-10

Source gene: RAB10

Class: DEG_SCF_FBW7_2

Location: 171:178

E3 ligase: FBXW7

DEGRON score: 0.5272

ASA_SCORE: 98.7

COIL: 0.6844

CONS_SCORE: 0.4078

DSS_SCORE: 0.3602

HELIX: 0.2946

FCONS_SCORE: 0.8217

RIG_SCORE: 0.7872

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P175H	TCGA-F7-A624	HNSC	TCGA	LRKTPVKE	DEG_SCF_FBW7_2	0.7694
p.P175H	DO44440	HNSC	ICGC	LRKTPVKE	DEG_SCF_FBW7_2	0.7694
p.S181I	DO229025	LICA	ICGC	LRKTPVKE	DEG_SCF_FBW7_2	0.6944
p.S187I	DO229034	LICA	ICGC	LRKTPVKE	DEG_SCF_FBW7_2	0.5278
p.D185N	SIDM02029	Colorectal Carcinoma	GDSC	LRKTPVKE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61026	Ras-related protein Rab-10	DEG_SCF_FBW7_2	171:178	LRKTPVKE	FBXW7	0.5272	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons