DegronMD - P61266(STX1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R89W	TCGA-06-5416	GBM	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8634
p.R89W	DO10880	GBM	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8634
p.I81S	TCGA-98-8023	LUSC	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389
p.I81S	DO26668	LUSC	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389
p.D80G	TCGA-B5-A3FC	UCEC	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.D80G	DO41871	UCEC	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.N86T	TCGA-CG-5721	STAD	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.N86T	DO38192	STAD	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.G104W	TCGA-CV-6933	HNSC	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.G104W	DO14164	HNSC	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.S90F	TCGA-EB-A41B	SKCM	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6871
p.S90F	DO37611	SKCM	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6871
p.S90C	TCGA-EM-A2OZ	THCA	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.643
p.S90C	DO39708	THCA	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.643
p.N86S	TCGA-FI-A2D5	UCEC	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.N86S	DO41331	UCEC	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.N106K	TCGA-FU-A3HY	CESC	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.N106K	DO6284	CESC	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.A94E	DO228986	LICA	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.659
p.Q101K	DO229032	LICA	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1944
p.Q97R	SIDM00817	Kidney Carcinoma	GDSC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056
p.Q97R	ACH-002191	Kidney Cancer	CCLE	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056
p.Q97R	RCC-JW	kidney	COSMIC	VRSKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056

Kaplan plot for STX1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STX1B

UniProt ID: P61266

Entrez ID: 112755

Protein name: Syntaxin-1B (Syntaxin-1B1) (Syntaxin-1B2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STX1B in