DegronMD

Uniprot ID: P61266

Source protein: Syntaxin-1B

Source gene: STX1B

Class: DEG_APCC_DBOX_1

Location: 88:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8049

ASA_SCORE: 75.2556

COIL: 0.0202

CONS_SCORE: 0.4807

DSS_SCORE: 0.3856

HELIX: 0.981

FCONS_SCORE: 1.5278

RIG_SCORE: 0.7784

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R89W	TCGA-06-5416	GBM	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	0.8634
p.R89W	DO10880	GBM	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.8634
p.I81S	TCGA-98-8023	LUSC	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	0.1389
p.I81S	DO26668	LUSC	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.1389
p.D80G	TCGA-B5-A3FC	UCEC	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	0.1111
p.D80G	DO41871	UCEC	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.1111
p.N86T	TCGA-CG-5721	STAD	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	0.2778
p.N86T	DO38192	STAD	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.2778
p.G104W	TCGA-CV-6933	HNSC	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	0.1111
p.G104W	DO14164	HNSC	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.1111
p.S90F	TCGA-EB-A41B	SKCM	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	0.6871
p.S90F	DO37611	SKCM	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.6871
p.S90C	TCGA-EM-A2OZ	THCA	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	0.643
p.S90C	DO39708	THCA	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.643
p.N86S	TCGA-FI-A2D5	UCEC	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	0.2778
p.N86S	DO41331	UCEC	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.2778
p.N106K	TCGA-FU-A3HY	CESC	TCGA	VRSKLKAIE	DEG_APCC_DBOX_1	0.0556
p.N106K	DO6284	CESC	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.0556
p.A94E	DO228986	LICA	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.659
p.Q101K	DO229032	LICA	ICGC	VRSKLKAIE	DEG_APCC_DBOX_1	0.1944
p.Q97R	SIDM00817	Kidney Carcinoma	GDSC	VRSKLKAIE	DEG_APCC_DBOX_1	0.3056
p.Q97R	ACH-002191	Kidney Cancer	CCLE	VRSKLKAIE	DEG_APCC_DBOX_1	0.3056
p.Q97R	RCC-JW	kidney	COSMIC	VRSKLKAIE	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61266	Syntaxin-1B	DEG_APCC_DBOX_1	88:96	VRSKLKAIE	APC,CDC20,FZR1	0.8049	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons