DegronMD - P61587(RND3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D232Y	TCGA-05-4427	LUAD	TCGA	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.2778
p.E225D	TCGA-A5-A0G2	UCEC	TCGA	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.5647
p.L233V	TCGA-B8-5162	KIRC	TCGA	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.R216W	TCGA-CU-A0YO	BLCA	TCGA	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1667
p.R216W	ACH-000999	Colon/Colorectal Cancer	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1667
p.K235T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation substituting flanking lysine	0.3056
p.K235T	ACH-000981	Leukemia	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation substituting flanking lysine	0.3056
p.K235T	DND-41	haematopoietic and lymphoid tissue	COSMIC	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation substituting flanking lysine	0.3056
p.R223G	SIDM00537	Colorectal Carcinoma	GDSC	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7568
p.R223G	ACH-000982	Colon/Colorectal Cancer	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7568
p.R223G	ACH-001345	Colon/Colorectal Cancer	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7568
p.R223G	GP5d	large intestine	COSMIC	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7568
p.H219R	SIDM00217	Colorectal Carcinoma	GDSC	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.H219R	ACH-000999	Colon/Colorectal Cancer	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.H219R	SNU-1040	large intestine	COSMIC	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.A228T	SIDM00579	Neuroblastoma	GDSC	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.6028
p.A228T	ACH-002277	Neuroblastoma	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.6028
p.A228T	NB(TU)1-10	autonomic ganglia	COSMIC	SRPELSAVA	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.6028

Kaplan plot for RND3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RND3

UniProt ID: P61587

Entrez ID: 390

Protein name: Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RND3 in