DegronMD

Uniprot ID: P61587

Source protein: Rho-related GTP-binding protein RhoE

Source gene: RND3

Class: DEG_APCC_DBOX_1

Location: 222:230

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9917

ASA_SCORE: 81.9778

COIL: 0.6671

CONS_SCORE: 0.5767

DSS_SCORE: 0.5883

HELIX: 0.297

FCONS_SCORE: 1.1327

RIG_SCORE: 0.6918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D232Y	TCGA-05-4427	LUAD	TCGA	SRPELSAVA	DEG_APCC_DBOX_1	0.2778
p.E225D	TCGA-A5-A0G2	UCEC	TCGA	SRPELSAVA	DEG_APCC_DBOX_1	0.5647
p.L233V	TCGA-B8-5162	KIRC	TCGA	SRPELSAVA	DEG_APCC_DBOX_1	0.25
p.R216W	TCGA-CU-A0YO	BLCA	TCGA	SRPELSAVA	DEG_APCC_DBOX_1	0.1667
p.R216W	ACH-000999	Colon/Colorectal Cancer	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	0.1667
p.K235T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRPELSAVA	DEG_APCC_DBOX_1	0.3056
p.K235T	ACH-000981	Leukemia	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	0.3056
p.K235T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	SRPELSAVA	DEG_APCC_DBOX_1	0.3056
p.R223G	SIDM00537	Colorectal Carcinoma	GDSC	SRPELSAVA	DEG_APCC_DBOX_1	0.7568
p.R223G	ACH-000982	Colon/Colorectal Cancer	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	0.7568
p.R223G	ACH-001345	Colon/Colorectal Cancer	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	0.7568
p.R223G	GP5d	large_intestine	COSMIC	SRPELSAVA	DEG_APCC_DBOX_1	0.7568
p.H219R	SIDM00217	Colorectal Carcinoma	GDSC	SRPELSAVA	DEG_APCC_DBOX_1	0.25
p.H219R	ACH-000999	Colon/Colorectal Cancer	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	0.25
p.H219R	SNU-1040	large_intestine	COSMIC	SRPELSAVA	DEG_APCC_DBOX_1	0.25
p.A228T	SIDM00579	Neuroblastoma	GDSC	SRPELSAVA	DEG_APCC_DBOX_1	0.6028
p.A228T	ACH-002277	Neuroblastoma	CCLE	SRPELSAVA	DEG_APCC_DBOX_1	0.6028
p.A228T	NB(TU)1-10	autonomic_ganglia	COSMIC	SRPELSAVA	DEG_APCC_DBOX_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61587	Rho-related GTP-binding protein RhoE	DEG_APCC_DBOX_1	222:230	SRPELSAVA	APC,CDC20,FZR1	0.9917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons