DegronMD - P61599(NAA20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A149T	TCGA-2W-A8YY	CESC	TCGA	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation rewiring degron network	0.1944
p.A149T	DO223732	CESC	ICGC	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation rewiring degron network	0.1944
p.R132K	TCGA-AP-A059	UCEC	TCGA	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation rewiring degron network	0.1389
p.R132K	DO41361	UCEC	ICGC	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation rewiring degron network	0.1389
p.Y150C	TCGA-CN-6997	HNSC	TCGA	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation rewiring degron network	0.1667
p.Y150C	DO14414	HNSC	ICGC	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation rewiring degron network	0.1667
p.D151N	TCGA-EJ-5519	PRAD	TCGA	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation rewiring degron network	0.1389
p.D151N	DO36247	PRAD	ICGC	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation rewiring degron network	0.1389
p.E144D	DO229022	LICA	ICGC	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation altering degron motif	0.6758
p.Y137C	SIDM00082	Melanoma	GDSC	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation blocking phosphorylation signal	0.7222
p.Y137C	ACH-001190	Skin Cancer	CCLE	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation blocking phosphorylation signal	0.7222
p.Y137C	SK-MEL-2	skin	COSMIC	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation blocking phosphorylation signal	0.7222
p.Y137H	SIDM00789	Colorectal Carcinoma	GDSC	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation blocking phosphorylation signal	0.7222
p.Y137H	ACH-000997	Colon/Colorectal Cancer	CCLE	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation blocking phosphorylation signal	0.7222
p.Y137H	HCT-15	large intestine	COSMIC	SASNGE	DEG_Kelch_Keap1_1	139:144	Mutation blocking phosphorylation signal	0.7222

Kaplan plot for NAA20 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NAA20

UniProt ID: P61599

Entrez ID: 51126

Protein name: N-alpha-acetyltransferase 20 (EC 2.3.1.254) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB complex subunit NAT5) (NatB catalytic subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NAA20 in